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Home / Primary Antibodies / Monoclonal Antibodies

Anti-RNF20 Antibody Picoband® (monoclonal, 3C6E2)

SKU : BHA21004825

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Mfr.No.	M03457-4, M03457-4-10ug, M03457-4-Biotin, M03457-4-Cy3, M03457-4-Dylight488, M03457-4-Dylight550, M03457-4-Dylight594, M03457-4-FITC, M03457-4-HRP, M03457-4-APC, M03457-4-PE, M03457-4-iFluor647, M03457-4-carrier-free
Alternative Names	survival of motor neuron 1, telomeric/survival of motor neuron 2, centromeric
Background	E3 ubiquitin-protein ligase BRE1A is an enzyme that in humans is encoded by the RNF20 gene. The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS).
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-RNF20 Antibody Picoband® (monoclonal, 3C6E2) catalog # M03457-4. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common s
Host	Mouse
Immunogen Region	E.coli-derived human RNF20 recombinant protein (Position: E123-S389).
Isotype	IgG2b
Molecular Weight	114 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Survival motor neuron protein; Component of gems 1; Gemin-1; SMN1; SMN, SMNT; SMN2; SMNC
Tissue Specificity	Expressed in a wide variety of tissues. Expressed at high levels in brain, kidney and liver, moderate levels in skeletal and cardiac muscle, and low levels in fibroblasts and lymphocytes. Also seen at high levels in spinal cord. Present in osteoclasts and mononuclear cells (at protein level).
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q5VTR2
Gene Id	56254
Gene Name	RNF20
Clone No	Clone: 3C6E2
Subcellular Location	Nucleus, gem

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat

Reference	1. Blank, M., Tang, Y., Yamashita, M., Burkett, S. S., Cheng, S. Y., Zhang, Y. E. A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20. Nature Med. 18: 227-234, 2012. 2. Cortez, J. T., Montauti, E., Shifrut, E., Gatchalian, J., Zhang, Y., Shaked, O., Xu, Y., Roth, T. L., Simeonov, D. R., Zhang, Y., Chen, S., Li, Z., and 13 others. CRISPR screen in regulatory T cells reveals modulators of Foxp3. Nature 582: 416-420, 2020. 3. Dickinson, M. E., Flenniken, A. M., Ji, X., Teboul, L., Wong, M. D., White, J. K., Meehan, T. F., Weninger, W. J., Westerberg, H., Adissu, H., Baker, C. N., Bower, L., and 73 others. High-throughput discovery of novel developmental phenotypes. Nature 537: 508-514, 2016. Note: Erratum: Nature 551: 398 only, 2017.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004825-1	M03457-4	-	100 ug	$370		Add to Cart
BHA21004825-2	M03457-4-10ug	Sample	10 ug	$99		Add to Cart
BHA21004825-3	M03457-4-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004825-4	M03457-4-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004825-5	M03457-4-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004825-6	M03457-4-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004825-7	M03457-4-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004825-8	M03457-4-FITC	FITC	100 ug	$570		Add to Cart
BHA21004825-9	M03457-4-HRP	HRP	100 ug	$570		Add to Cart
BHA21004825-10	M03457-4-APC	APC	100 ug	$670		Add to Cart
BHA21004825-11	M03457-4-PE	PE	100 ug	$670		Add to Cart
BHA21004825-12	M03457-4-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004825-13	M03457-4-carrier-free	carrier-free	100 ug	$370		Add to Cart

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