JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Primary Antibodies / Monoclonal Antibodies

Anti-PTBP1 Antibody Picoband®(monoclonal, 3H12)

SKU : BHA21002444

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Boster

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	M01798-1, M01798-1-10ug, M01798-1-Biotin, M01798-1-Cy3, M01798-1-Dylight488, M01798-1-Dylight550, M01798-1-Dylight594, M01798-1-FITC, M01798-1-HRP, M01798-1-APC, M01798-1-PE, M01798-1-iFluor647, M01798-1-carrier-free
Alternative Names	Polypyrimidine tract-binding protein 1
Background	Polypyrimidine tract-binding protein 1 is a protein that in humans is encoded by the PTBP1 gene. It is mapped to 19p13.3. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alteatively spliced transcript variants encoding different isoforms have been described.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-PTBP1 Antibody Picoband® (monoclonal, 3H12) catalog # M01798-1. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET tuover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBL
Host	Mouse
Immunogen Region	E.coli-derived human PTBP1 recombinant protein (Position: M1-A504).
Isotype	Mouse IgG2b
Molecular Weight	57 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Polypyrimidine tract-binding protein 1; PTB; 57 kDa RNA-binding protein PPTB-1; Heterogeneous nuclear ribonucleoprotein I; hnRNP I; PTBP1; PTB
Tissue Specificity	Widely expressed in fetal and adult tissues.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	P26599
Gene Id	5725
Gene Name	PTBP1
Clone No	Clone: 3H12
Subcellular Location	Cytoplasm, cytoskeleton . Cell projection, ruffle . Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles. Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat<br> Immunocytochemistry/Immunofluorescence, 2ug/ml, Human<br> Immunofluorescence, 2ug/ml, Human, Rat<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Charlet-B., N., Logan, P., Singh, G., Cooper, T. A. Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alteative splicing. Molec. Cell 9: 649-658, 2002.<br /><br />2. David, C. J., Chen, M., Assanah, M., Canoll, P., Manley, J. L. HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature 463: 364-368, 2010.<br /><br />3. Ghetti, A., Pinol-Roma, S., Michael, W. M., Morandi, C., Dreyfuss, G. HNRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs. Nucleic Acids Res. 20: 3671-3678, 1992.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002444-1	M01798-1	-	100 ug	$370		Add to Cart
BHA21002444-2	M01798-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21002444-3	M01798-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002444-4	M01798-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002444-5	M01798-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002444-6	M01798-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002444-7	M01798-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002444-8	M01798-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21002444-9	M01798-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21002444-10	M01798-1-APC	APC	100 ug	$670		Add to Cart
BHA21002444-11	M01798-1-PE	PE	100 ug	$670		Add to Cart
BHA21002444-12	M01798-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002444-13	M01798-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.