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Home / Primary Antibodies / Monoclonal Antibodies

Anti-PARP/PARP1 Picoband® Antibody (monoclonal, 2I2H4)

SKU : BHA21003143

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Mfr.No.	M00122-4, M00122-4-10ug, M00122-4-Biotin, M00122-4-Cy3, M00122-4-Dylight488, M00122-4-Dylight550, M00122-4-Dylight594, M00122-4-FITC, M00122-4-HRP, M00122-4-APC, M00122-4-PE, M00122-4-iFluor647, M00122-4-carrier-free
Alternative Names	interleukin 6
Background	Poly (ADP-ribose) polymerase 1 (PARP1), also known as ADPRT or PPOL is an enzyme that in humans is encoded by the PARP1 gene. PARP1 gene is mapped to 1q42.12. This gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl)transferase, which modifies various nuclear proteins by poly (ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-PARP/PARP1 Picoband® Antibody (monoclonal, 2I2H4) catalog # M00122-4. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on
Host	Mouse
Immunogen Region	E.coli-derived human PARP recombinant protein (Position: Q670-R858). Human PARP shares 94% and 95% amino acid (aa) sequence identity with mouse and rat PARP, respectively.
Isotype	Mouse IgG1
Molecular Weight	116 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Interleukin-6; IL-6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2; IL6; IFNB2
Tissue Specificity	Ubiquituous. Expressed in platelets.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	P09874
Gene Id	142
Gene Name	PARP1
Clone No	Clone: 2I2H4
Subcellular Location	Secreted

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, ICC, IF, Flow Cytometry
Description	Weste blot, 0.1-0.25ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Ambrose, H. E., Willimott, S., Beswick, R. W., Dantzer, F., Menissier de Murcia, J., Yelamos, J., Wagner, S. D. Poly(ADP-ribose) polymerase-1 (Parp-1)-deficient mice demonstrate abnormal antibody responses. Immunology 127: 178-186, 2008.<br /><br />2. Doege, C. A., Inoue, K., Yamashita, T., Rhee, D. B., Travis, S., Fujita, R., Guaieri, P., Bhagat, G., Vanti, W. B., Shih, A., Levine, R. L., Nik, S., Chen, E. I., Abeliovich, A. Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2. Nature 488: 652-655, 2012.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003143-1	M00122-4	-	100 ug	$370		Add to Cart
BHA21003143-2	M00122-4-10ug	Sample	10 ug	$99		Add to Cart
BHA21003143-3	M00122-4-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003143-4	M00122-4-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003143-5	M00122-4-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003143-6	M00122-4-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003143-7	M00122-4-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003143-8	M00122-4-FITC	FITC	100 ug	$570		Add to Cart
BHA21003143-9	M00122-4-HRP	HRP	100 ug	$570		Add to Cart
BHA21003143-10	M00122-4-APC	APC	100 ug	$670		Add to Cart
BHA21003143-11	M00122-4-PE	PE	100 ug	$670		Add to Cart
BHA21003143-12	M00122-4-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003143-13	M00122-4-carrier-free	carrier-free	100 ug	$370		Add to Cart

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