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Home / Primary Antibodies / Monoclonal Antibodies

Anti-p23/PTGES3 Antibody Picoband® (monoclonal, 9D3D1)

SKU : BHA21004155

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Mfr.No.	M04136-3, M04136-3-10ug, M04136-3-Biotin, M04136-3-Cy3, M04136-3-Dylight488, M04136-3-Dylight550, M04136-3-Dylight594, M04136-3-FITC, M04136-3-HRP, M04136-3-APC, M04136-3-PE, M04136-3-iFluor647, M04136-3-carrier-free
Alternative Names	ubiquitin like modifier activating enzyme 2
Background	Prostaglandin E synthase 3 (cytosolic)is anenzymethat in humans is encoded by the PTGES3gene. It is mapped to 12q13.3; 12. This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alteative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-p23/PTGES3 Antibody Picoband® (monoclonal, 9D3D1) catalog # M04136-3. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/S
Host	Mouse
Immunogen Region	E.coli-derived human p23/PTGES3 recombinant protein (Position: M1-K79).
Isotype	Mouse IgG2b
Molecular Weight	23 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	SUMO-activating enzyme subunit 2; Anthracycline-associated resistance ARX; Ubiquitin-like 1-activating enzyme E1B; Ubiquitin-like modifier-activating enzyme 2; UBA2; SAE2, UBLE1B; HRIHFB2115
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q15185
Gene Id	10728
Gene Name	PTGES3
Clone No	Clone: 9D3D1
Subcellular Location	Nucleus; Cytoplasm

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, ICC, IF, Flow Cytometry
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Weaver AJ, Sullivan WP, Felts SJ, et al. (2000). "Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone". J. Biol. Chem. 275 (30): 2304523052. <br /><br />2. Tanioka T, Nakatani Y, Semmyo N, et al. (2000). "Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis". J. Biol. Chem. 275 (42): 3277532782. <br /><br />3. Dittmar KD, Pratt WB (1997). "Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation". J. Biol. Chem. 272 (20): 1304713054.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004155-1	M04136-3	-	100 ug	$370		Add to Cart
BHA21004155-2	M04136-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21004155-3	M04136-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004155-4	M04136-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004155-5	M04136-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004155-6	M04136-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004155-7	M04136-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004155-8	M04136-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21004155-9	M04136-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21004155-10	M04136-3-APC	APC	100 ug	$670		Add to Cart
BHA21004155-11	M04136-3-PE	PE	100 ug	$670		Add to Cart
BHA21004155-12	M04136-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004155-13	M04136-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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