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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Neurofibromin/NF1 Antibody Picoband® (monoclonal, 4C6F10)

SKU : BHA21003839

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Mfr.No.	M00043, M00043-10ug, M00043-Biotin, M00043-Cy3, M00043-Dylight488, M00043-Dylight550, M00043-Dylight594, M00043-FITC, M00043-HRP, M00043-APC, M00043-PE, M00043-iFluor647, M00043-carrier-free
Alternative Names	signal transducer and activator of transcription 1, 91kDa
Background	Neurofibromin 1 (NF1) is a gene in humans that is located on chromosome 17. This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alteatively spliced transcript variants encoding different isoforms have also been described for this gene.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Neurofibromin/NF1 Antibody Picoband® (monoclonal, 4C6F10) catalog # M00043. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signali
Host	Mouse
Immunogen Region	E.coli-derived human Neurofibromin/NF1 recombinant protein (Position: R160-Q270).
Isotype	Mouse IgG2b
Molecular Weight	319 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84; STAT1
Tissue Specificity	Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level).
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P21359
Gene Id	4763
Gene Name	NF1
Clone No	Clone: 4C6F10
Subcellular Location	Nucleus. Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC, Flow Cytometry
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human, Mouse, Rat Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human

Reference	1. Scheffzek K, Welti S (2012). "Neurofibromin: Protein Domains and Functional Characteristics". In Upadhyaya M, Cooper D (eds.). Neurofibromatosis Type 1. Berlin, Heidelberg: Springer. pp. 305326. 2. Trovó-Marqui AB, Tajara EH (July 2006). "Neurofibromin: a general outlook". Clinical Genetics. 70 (1): 113. 3. Peltonen S, Pöyhönen M (2012). "Clinical Diagnosis and Atypical Forms of NF1". In Upadhyaya M, Cooper D (eds.). Neurofibromatosis Type 1. Berlin, Heidelberg: Springer. pp. 1730.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003839-1	M00043	-	100 ug	$370		Add to Cart
BHA21003839-2	M00043-10ug	Sample	10 ug	$99		Add to Cart
BHA21003839-3	M00043-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003839-4	M00043-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003839-5	M00043-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003839-6	M00043-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003839-7	M00043-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003839-8	M00043-FITC	FITC	100 ug	$570		Add to Cart
BHA21003839-9	M00043-HRP	HRP	100 ug	$570		Add to Cart
BHA21003839-10	M00043-APC	APC	100 ug	$670		Add to Cart
BHA21003839-11	M00043-PE	PE	100 ug	$670		Add to Cart
BHA21003839-12	M00043-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003839-13	M00043-carrier-free	carrier-free	100 ug	$370		Add to Cart

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