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Home / Primary Antibodies / Monoclonal Antibodies

Anti-MPI Antibody Picoband® (monoclonal, 11I4)

SKU : BHA21002388

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Mfr.No.	M00175, M00175-10ug, M00175-Biotin, M00175-Cy3, M00175-Dylight488, M00175-Dylight550, M00175-Dylight594, M00175-FITC, M00175-HRP, M00175-APC, M00175-PE, M00175-iFluor647, M00175-carrier-free
Alternative Names	mannose phosphate isomerase
Background	Mannose-6 phosphate isomerase (MPI), alteately phosphomannose isomerase (PMI), is an enzyme which facilitates the interconversion of fructose 6-phosphate (F6P) and mannose-6-phosphate (M6P). It also plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alteative splicing results in multiple transcript variants. This MPI gene is mapped to 15q24.1.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-MPI Antibody Picoband® (monoclonal, 11I4) catalog # M00175. Tested in IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Host	Mouse
Immunogen Region	E. coli-derived human MPI recombinant protein (Position: A2-K99). Human MPI shares 88.8% and 86.7% amino acid (aa) sequence identity with mouse and rat MPI, respectively.
Isotype	Mouse IgG1
Molecular Weight	47 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; MPI; PMI1
Tissue Specificity	Expressed in all tissues, but more abundant in heart, brain and skeletal muscle.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.01mg NaN<sub>3</sub>.

Uniprot	P34949
Gene Id	4351
Gene Name	MPI
Clone No	Clone: 11I4
Subcellular Location	Cytoplasm

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br>

Reference	1. Jaeken, J., Matthijs, G., Saudubray, J.-M., Dionisi-Vici, C., Bertini, E., de Lonlay, P., Henri, H., Carchon, H., Schollen, E., Van Schaftingen, E. Phosphomannose isomerase deficiency: a carbohydrate-deficient glycoprotein syndrome with hepatic-intestinal presentation. (Letter) Am. J. Hum. Genet. 62: 1535-1539, 1998.<br /><br />2. Schollen, E., Dorland, L., de Koning, T. J., Van Diggelen, O. P., Huijmans, J. G. M., Marquardt, T., Babovic-Vuksanovic, D., Patterson, M., Imtiaz, F., Winchester, B., Adamowicz, M., Pronicka, E., Freeze, H., Matthijs, G. Genomic organization of the human phosphomannose isomerase (MPI) gene and mutation analysis in patients with congenital disorders of glycosylation type Ib (CDG-Ib). Hum. Mutat. 16: 247-252, 2000.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002388-1	M00175	-	100 ug	$370		Add to Cart
BHA21002388-2	M00175-10ug	Sample	10 ug	$99		Add to Cart
BHA21002388-3	M00175-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002388-4	M00175-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002388-5	M00175-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002388-6	M00175-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002388-7	M00175-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002388-8	M00175-FITC	FITC	100 ug	$570		Add to Cart
BHA21002388-9	M00175-HRP	HRP	100 ug	$570		Add to Cart
BHA21002388-10	M00175-APC	APC	100 ug	$670		Add to Cart
BHA21002388-11	M00175-PE	PE	100 ug	$670		Add to Cart
BHA21002388-12	M00175-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002388-13	M00175-carrier-free	carrier-free	100 ug	$370		Add to Cart

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