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Home / Primary Antibodies / Monoclonal Antibodies

Anti-MERS-CoV Spike Protein S2 Monoclonal Antibody

SKU : BHA10324349

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	E-AB-V1299
Background	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
Host	Mouse
Immunogen	Recombinant MERS-CoV Spike/S2 Protein (S2 Subunit, aa 726-1296, His Tag)
Isotype	IgG1
Reactivity	MERS-CoV

Buffer	0.2 um filtered solution in PBS
Concentration	1mg/mL
Purification	Protein A Affinity
Storage	Store at -20?. Avoid freeze / thaw cycles.

Applications	WB
Dilution	WB 1:1000-1:5000

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA10324349	E-AB-V1299	50?L	$250		Add to Cart
BHA10324349	E-AB-V1299	100?L	$415		Add to Cart

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