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Home / Primary Antibodies / Monoclonal Antibodies

Anti-ME1 Antibody Picoband® (monoclonal, 5E5F7)

SKU : BHA21004429

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Mfr.No.	M03449, M03449-10ug, M03449-Biotin, M03449-Cy3, M03449-Dylight488, M03449-Dylight550, M03449-Dylight594, M03449-FITC, M03449-HRP, M03449-APC, M03449-PE, M03449-iFluor647, M03449-carrier-free
Alternative Names	survival of motor neuron 1, telomeric/survival of motor neuron 2, centromeric
Background	NADP-dependent malic enzyme is a protein that in humans is encoded by the ME1 gene. This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-ME1 Antibody Picoband® (monoclonal, 5E5F7) catalog # M03449. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common s
Host	Mouse
Immunogen Region	E.coli-derived human ME1 recombinant protein (Position: M1-Q572).
Isotype	Mouse IgG1
Molecular Weight	64 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Survival motor neuron protein; Component of gems 1; Gemin-1; SMN1; SMN, SMNT; SMN2; SMNC
Tissue Specificity	Expressed in a wide variety of tissues. Expressed at high levels in brain, kidney and liver, moderate levels in skeletal and cardiac muscle, and low levels in fibroblasts and lymphocytes. Also seen at high levels in spinal cord. Present in osteoclasts and mononuclear cells (at protein level).
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P48163
Gene Id	4199
Gene Name	ME1
Clone No	Clone: 5E5F7
Subcellular Location	Nucleus, gem

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human, Rat<br>

Reference	1. Chen, T.-R., McMorris, F. A., Creagan, R., Ricciuti, F. C., Tischfield, J., Ruddle, F. H. Assignment of the genes for malate oxidoreductase decarboxylating to chromosome 6 and peptidase B and lactate dehydrogenase B to chromosome 12 in man. Am. J. Hum. Genet. 25: 200-207, 1973.<br /><br />2. Cohen, P. T. W., Omenn, G. S. Genetic variation of the cytoplasmic and mitochondrial malic enzymes in the monkey: Macaca nemestrina. Biochem. Genet. 7: 289-301, 1972. <br /><br />3. Gimelbrant, A., Hutchinson, J. N., Thompson, B. R., Chess, A. Widespread monoallelic expression on human autosomes. Science 318: 1136-1140, 2007.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004429-1	M03449	-	100 ug	$370		Add to Cart
BHA21004429-2	M03449-10ug	Sample	10 ug	$99		Add to Cart
BHA21004429-3	M03449-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004429-4	M03449-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004429-5	M03449-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004429-6	M03449-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004429-7	M03449-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004429-8	M03449-FITC	FITC	100 ug	$570		Add to Cart
BHA21004429-9	M03449-HRP	HRP	100 ug	$570		Add to Cart
BHA21004429-10	M03449-APC	APC	100 ug	$670		Add to Cart
BHA21004429-11	M03449-PE	PE	100 ug	$670		Add to Cart
BHA21004429-12	M03449-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004429-13	M03449-carrier-free	carrier-free	100 ug	$370		Add to Cart

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