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Home / Primary Antibodies / Monoclonal Antibodies

Anti-MDH2 Antibody Picoband® (monoclonal, 5D8C1)

SKU : BHA21004434

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Mfr.No.	M04803-1, M04803-1-10ug, M04803-1-Biotin, M04803-1-Cy3, M04803-1-Dylight488, M04803-1-Dylight550, M04803-1-Dylight594, M04803-1-FITC, M04803-1-HRP, M04803-1-APC, M04803-1-PE, M04803-1-iFluor647, M04803-1-carrier-free
Alternative Names	cofilin 2
Background	Malate dehydrogenase, mitochondrial also known as malate dehydrogenase 2 is an enzyme that in humans is encoded by the MDH2 gene. Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-MDH2 Antibody Picoband® (monoclonal, 5D8C1) catalog # M04803-1. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the m
Host	Mouse
Immunogen Region	E.coli-derived human MDH2 recombinant protein (Position: A9-L223). Human MDH2 shares 97.7% and 98.1% amino acid (aa) sequence identity with mouse and rat MDH2, respectively.
Isotype	Mouse IgG2b
Molecular Weight	36 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Cofilin-2; Cofilin, muscle isoform; CFL2
Tissue Specificity	Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P40926
Gene Id	4191
Gene Name	MDH2
Clone No	Clone: 5D8C1
Subcellular Location	Cytoskeleton. Nucleus matrix.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC, ICC, IF
Description	Weste blot, 0.25-0.5 ug/ml, Human<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br>

Reference	1. Ait-El-Mkadem, S., Dayem-Quere, M., Gusic, M., Chaussenot, A., Bannwarth, S., Francois, B., Genin, E. C., Fragaki, K., Volker-Touw, C. L. M., Vasnier, C., Serre, V., van Gassen, K. L. I., and 24 others. Mutations in MDH2, encoding a Krebs cycle enzyme, cause early-onset severe encephalopathy. Am. J. Hum. Genet. 100: 151-159, 2017. <br /><br />2. Benn, P., Che, C. J., Bruns, G., Craig, I. W., Croce, C. M. Assignment of the genes for human beta-glucuronidase and mitochondrial malate dehydrogenase to the region pter-q22 of chromosome 7. Cytogenet. Cell Genet. 19: 273-280, 1977. <br /><br />3. Blake, N. M. Malate dehydrogenase types in the Asian-Pacific area, and a description of new phenotypes. Hum. Genet. 43: 69-80, 1978.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004434-1	M04803-1	-	100 ug	$370		Add to Cart
BHA21004434-2	M04803-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21004434-3	M04803-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004434-4	M04803-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004434-5	M04803-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004434-6	M04803-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004434-7	M04803-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004434-8	M04803-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21004434-9	M04803-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21004434-10	M04803-1-APC	APC	100 ug	$670		Add to Cart
BHA21004434-11	M04803-1-PE	PE	100 ug	$670		Add to Cart
BHA21004434-12	M04803-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004434-13	M04803-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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