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Home / Primary Antibodies / Monoclonal Antibodies

Anti-IL1RA Antibody (monoclonal, 12C13)

SKU : BHA21003395

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Mfr.No.	M00651-1, M00651-1-10ug, M00651-1-Biotin, M00651-1-Cy3, M00651-1-Dylight488, M00651-1-Dylight550, M00651-1-Dylight594, M00651-1-FITC, M00651-1-HRP, M00651-1-APC, M00651-1-PE, M00651-1-iFluor647, M00651-1-carrier-free
Alternative Names	major vault protein
Background	The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alteatively spliced transcript variants encoding distinct isoforms have been reported.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-IL1RA Antibody Picoband® (monoclonal, 12C13) catalog # M00651-1. Tested in ELISA applications. This antibody reacts with Rat.
Function	Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and
Host	Mouse
Immunogen Region	E. coli-derived rat IL1RA recombinant protein (Position: H27-Q178). Rat IL1RA shares 77.6% and 90.7% amino acid (aa) sequence identity with human and mouse IL1RA, respectively.
Isotype	Mouse IgG2b
Molecular Weight	100-110 kDa
Reactivity	Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Major vault protein; MVP; Lung resistance-related protein; MVP; LRP
Tissue Specificity	Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	P25086
Gene Id	60582
Gene Name	Il1
Clone No	Clone: 12C13
Subcellular Location	nuclear pore complex; Cytoplasm; perinuclear region

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA
Description	ELISA (Cap), 1-5ug/ml, Rat<br>

Reference	1. "Entrez Gene: IL1RN interleukin 1 receptor antagonist".<br /><br />2. Patterson D, Jones C, Hart I, Bleskan J, Berger R, Geyer D, Eisenberg SP, Smith MF, Arend WP (January 1993). "The human interleukin-1 receptor antagonist (IL1RN) gene is located in the chromosome 2q14 region". Genomics. 15 (1): 1736.<br /><br />3. Steinkasserer A, Spurr NK, Cox S, Jeggo P, Sim RB (July 1992). "The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci". Genomics. 13(3): 6547.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003395-1	M00651-1	-	100 ug	$370		Add to Cart
BHA21003395-2	M00651-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21003395-3	M00651-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003395-4	M00651-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003395-5	M00651-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003395-6	M00651-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003395-7	M00651-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003395-8	M00651-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21003395-9	M00651-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21003395-10	M00651-1-APC	APC	100 ug	$670		Add to Cart
BHA21003395-11	M00651-1-PE	PE	100 ug	$670		Add to Cart
BHA21003395-12	M00651-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003395-13	M00651-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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