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Home / Primary Antibodies / Monoclonal Antibodies

Anti-IFI16 Antibody Picoband® (monoclonal, 2I3D7)

SKU : BHA21004822

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Mfr.No.	M00848, M00848-10ug, M00848-Biotin, M00848-Cy3, M00848-Dylight488, M00848-Dylight550, M00848-Dylight594, M00848-FITC, M00848-HRP, M00848-APC, M00848-PE, M00848-iFluor647, M00848-carrier-free
Alternative Names	dihydrofolate reductase
Background	Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene. This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alteatively spliced transcript variants encoding different isoforms have been found for this gene.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-IFI16 Antibody Picoband® (monoclonal, 2I3D7) catalog # M00848. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2.
Host	Mouse
Immunogen Region	E.coli-derived human IFI16 recombinant protein (Position: E183-K743).
Isotype	IgG2b
Molecular Weight	98 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Dihydrofolate reductase; DHFR
Tissue Specificity	Widely expressed in fetal and adult tissues, including throughout the fetal and adult brains and whole blood. Expression is higher in the adult brain than in the fetal brain.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q16666
Gene Id	3428
Gene Name	IFI16
Clone No	Clone: 2I3D7
Subcellular Location	Mitochondrion. Cytoplasm

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB, ICC, IF, Flow Cytometry
Description	Weste blot, 0.25-0.5 ug/ml, Human Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human

Reference	1. Choubey, D., Snoddy, J., Chaturvedi, V., Toniato, E., Opdenakker, G., Thakur, A., Samanta, H., Engel, D. A., Lengyel, P. Interferons as gene activators: indications for repeated gene duplication during the evolution of a cluster of interferon-activatable genes on murine chromosome 1. J. Biol. Chem. 264: 17182-17189, 1989. 2. Kerur, N., Veettil, M. V., Sharma-Walia, N., Bottero, V., Sadagopan, S., Otageri, P., Chandran, B. IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi sarcoma-associated herpesvirus infection. Cell Host Microbe 9: 363-375, 2011. 3. Kingsmore, S. F., Snoddy, J., Choubey, D., Lengyel, P., Seldin, M. F. Physical mapping of a family of interferon-activated genes, serum amyloid P-component, and alpha-spectrin on mouse chromosome 1. Immunogenetics 30: 169-174, 1989.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004822-1	M00848	-	100 ug	$370		Add to Cart
BHA21004822-2	M00848-10ug	Sample	10 ug	$99		Add to Cart
BHA21004822-3	M00848-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004822-4	M00848-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004822-5	M00848-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004822-6	M00848-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004822-7	M00848-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004822-8	M00848-FITC	FITC	100 ug	$570		Add to Cart
BHA21004822-9	M00848-HRP	HRP	100 ug	$570		Add to Cart
BHA21004822-10	M00848-APC	APC	100 ug	$670		Add to Cart
BHA21004822-11	M00848-PE	PE	100 ug	$670		Add to Cart
BHA21004822-12	M00848-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004822-13	M00848-carrier-free	carrier-free	100 ug	$370		Add to Cart

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