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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Human Hsp70 DyLight® 488 conjugated HSPA1A Antibody(monoclonal, 3H5)

SKU : BHA21001837

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Mfr.No.	M00949-Dyl488
Alternative Names	heat shock protein family A (Hsp70) member 1A
Background	HSPA1 (heat shock 70kDa protein 1A) also known as HSP70-1, HSPA1A, HSP70-1A, HSP72 or HSP70I, is a protein that in humans is encoded by the HSPA1A gene. This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. The HSPA1A gene encodes a predicted 641-amino acid protein. The HSPA1 gene is mapped on 6p21.33. Shimizu et al. (1999) found that peripheral blood mononuclear cells of 18 major depression patients expressed a short HSPA1A transcript that utilized exon 1 rather than exon 2, which is found in the more common HSPA1A transcript. No protein was associated with expression of this short HSPA1A mRNA, possibly due to lack of a TATA box or loss of inteal ribosome binding sites. Treatment with BGP-15, a pharmacologic inducer of Hsp72 that can protect against obesity-induced insulin resistance, improved muscular architecture, strength, and contractile function in severely affected diaphragm muscles in mdx dystrophic mice.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Human Hsp70 DyLight® 488 conjugated HSPA1A Antibody (monoclonal, 3H5) catalog # M00949-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.
Function	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissoc
Host	Mouse
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Hsp70, different from the related mouse sequence by five amino acids, and from the related rat sequence by three amino acids.
Isotype	Mouse IgG1
Molecular Weight	39 kDa
Reactivity	Human
Specificity	No cross reactivity with other proteins.
Synonyms	Heat shock 70 kDa protein 1A; Heat shock 70 kDa protein 1B
Note	Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Uniprot	P0DMV8
Gene Id	3303/3304
Gene Name	HSPA1A
Clone No	Clone: 3H5
Subcellular Location	Nucleus, centrosome, Cytoplasm.

Conjugates	DyLight 488

Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Form	Liquid
Storage	At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications	Flow Cytometry
Description	Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells

Reference	1. Becker, T., Hartl, F.-U., Wieland, F. CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes. J. Cell Biol. 158: 1277-1285, 2002.<br /><br />2. Gehrig, S. M., van der Poel, C., Sayer, T. A., Schertzer, J. D., Henstridge, D. C., Church, J. E., Lamon, S., Russell, A. P., Davies, K. E., Febbraio, M. A., Lynch, G. S. Hsp72 preserves muscle function and slows progression of severe muscular dystrophy. Nature 484: 394-398, 2012.<br /><br />3. Shimizu, S., Nomura, K., Ujihara, M., Demura, H. An additional exon of stress-inducible heat shock protein 70 gene (HSP70-1). Biochem. Biophys. Res. Commun. 257: 193-198, 1999.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001837-1	M00949-Dyl488	100 ug	-	$515		Add to Cart

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