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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Hsp70 HSPA1A Antibody Picoband® (monoclonal, 3H5)

SKU : BHA21001820

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Mfr.No.	M00949-2, M00949-2-10ug, M00949-2-Biotin, M00949-2-Cy3, M00949-2-Dylight488, M00949-2-Dylight550, M00949-2-Dylight594, M00949-2-FITC, M00949-2-HRP, M00949-2-APC, M00949-2-PE, M00949-2-iFluor647, M00949-2-carrier-free
Alternative Names	heat shock protein family A (Hsp70) member 1A/1B
Background	HSPA1 (heat shock 70kDa protein 1A) also known as HSP70-1, HSPA1A, HSP70-1A, HSP72 or HSP70I, is a protein that in humans is encoded by the HSPA1A gene. This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. The HSPA1A gene encodes a predicted 641-amino acid protein. The HSPA1 gene is mapped on 6p21.33. Shimizu et al. (1999) found that peripheral blood mononuclear cells of 18 major depression patients expressed a short HSPA1A transcript that utilized exon 1 rather than exon 2, which is found in the more common HSPA1A transcript. No protein was associated with expression of this short HSPA1A mRNA, possibly due to lack of a TATA box or loss of inteal ribosome binding sites. Treatment with BGP-15, a pharmacologic inducer of Hsp72 that can protect against obesity-induced insulin resistance, improved muscular architecture, strength, and contractile function in severely affected diaphragm muscles in mdx dystrophic mice.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Hsp70 HSPA1A Antibody Picoband® (monoclonal, 3H5) catalog # M00949-2. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissoc
Host	Mouse
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Hsp70, different from the related mouse sequence by five amino acids, and from the related rat sequence by three amino acids.
Isotype	Mouse IgG1
Molecular Weight	70 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Heat shock 70 kDa protein 1A; Heat shock 70 kDa protein 1B
Tissue Specificity	Ubiquitous.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P0DMV8
Gene Id	3303/3304
Gene Name	HSPA1A
Clone No	Clone: 3H5
Subcellular Location	Cytoplasm

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> Immunocytochemistry/Immunofluorescence, 2ug/ml<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells

Reference	1. Becker, T., Hartl, F.-U., Wieland, F. CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes. J. Cell Biol. 158: 1277-1285, 2002.<br /><br />2. Gehrig, S. M., van der Poel, C., Sayer, T. A., Schertzer, J. D., Henstridge, D. C., Church, J. E., Lamon, S., Russell, A. P., Davies, K. E., Febbraio, M. A., Lynch, G. S. Hsp72 preserves muscle function and slows progression of severe muscular dystrophy. Nature 484: 394-398, 2012.<br /><br />3. Shimizu, S., Nomura, K., Ujihara, M., Demura, H. An additional exon of stress-inducible heat shock protein 70 gene (HSP70-1). Biochem. Biophys. Res. Commun. 257: 193-198, 1999.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001820-1	M00949-2	100 ug	-	$370		Add to Cart
BHA21001820-2	M00949-2-10ug	10 ug	Sample	$99		Add to Cart
BHA21001820-3	M00949-2-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001820-4	M00949-2-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001820-5	M00949-2-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001820-6	M00949-2-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001820-7	M00949-2-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001820-8	M00949-2-FITC	100 ug	FITC	$570		Add to Cart
BHA21001820-9	M00949-2-HRP	100 ug	HRP	$570		Add to Cart
BHA21001820-10	M00949-2-APC	100 ug	APC	$670		Add to Cart
BHA21001820-11	M00949-2-PE	100 ug	PE	$670		Add to Cart
BHA21001820-12	M00949-2-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001820-13	M00949-2-carrier-free	100 ug	carrier-free	$370		Add to Cart

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