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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Hsp60/HSPD1 Antibody Picoband® (monoclonal, 6G2)

SKU : BHA21002268

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Mfr.No.	M01280-3, M01280-3-10ug, M01280-3-Biotin, M01280-3-Cy3, M01280-3-Dylight488, M01280-3-Dylight550, M01280-3-Dylight594, M01280-3-FITC, M01280-3-HRP, M01280-3-APC, M01280-3-PE, M01280-3-iFluor647, M01280-3-carrier-free
Alternative Names	heat shock protein family D (Hsp60) member 1
Background	HSP60 is a member of the chaperonin class of protein factors, which include the Escherichia coli groEL protein and the Rubisco subunit-binding protein of chloroplasts. It acts as a costimulator of human regulatory CD4-positive/CD25 -positive T cells, which inhibit lymphoproliferation and IFNG and TNF secretion by CD4-positive and CD8-positive T cells. HSP60 enhances Treg activity via TLR2, leading to activation of an intracellular signaling cascade that included p38, as well as inhibition of ERK phosphorylation. Suppression of target T cells is mediated by both cell-to-cell contact and by secretion of TGFB and IL10, and it leads to downregulation of ERK, NFKB, and TBET expression. The self-molecule HSP60 can downregulate adaptive immune responses by upregulating Tregs through TLR2 signaling.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Hsp60/HSPD1 Antibody Picoband® (monoclonal, 6G2) catalog # M01280-3. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptide
Host	Mouse
Immunogen Region	E.coli-derived human Hsp60/HSPD1 recombinant protein (Position: A260-Q496). Human Hsp60 shares 97% amino acid (aa) sequence identity with both mouse and rat Hsp60.
Isotype	Mouse IgG1
Molecular Weight	60 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	60 kDa heat shock protein, mitochondrial; 60 kDa chaperonin; Chaperonin 60; CPN60; Heat shock protein 60; HSP-60; Hsp60; HuCHA60; Mitochondrial matrix protein P1; P60 lymphocyte protein; HSPD1; HSP60
Tissue Specificity	Widely expressed. Overexpressed in prostate cancer.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	P10809
Gene Id	3329
Gene Name	HSPD1
Clone No	Clone: 6G2
Subcellular Location	Mitochondrion matrix.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> Immunocytochemistry/Immunofluorescence, 5ug/ml<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells<br>

Reference	1. Cheng, M. Y.; Hartl, F.-U.; Martin, J.; Pollock, R. A.; Kalousek, F.; Neupert, W.; Hallberg, E. M.; Hallberg, R. L.; Horwich, A. L. : Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria. Nature 337: 620-625, 1989. <br /><br />2. Zanin-Zhorov, A.; Cahalon, L.; Tal, G.; Margalit, R.; Lider, O.; Cohen, I. R. : Heat shock protein 60 enhances CD4+CD25+ regulatory T cell function via innate TLR2 signaling. J. Clin. Invest. 116: 2022-2032, 2006.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002268-1	M01280-3	-	100 ug	$370		Add to Cart
BHA21002268-2	M01280-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21002268-3	M01280-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002268-4	M01280-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002268-5	M01280-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002268-6	M01280-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002268-7	M01280-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002268-8	M01280-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21002268-9	M01280-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21002268-10	M01280-3-APC	APC	100 ug	$670		Add to Cart
BHA21002268-11	M01280-3-PE	PE	100 ug	$670		Add to Cart
BHA21002268-12	M01280-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002268-13	M01280-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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