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Home / Primary Antibodies / Monoclonal Antibodies

Anti-HNF-4-alpha Antibody Picoband® (monoclonal, 6C8E9)

SKU : BHA21004159

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Mfr.No.	M00389-2, M00389-2-10ug, M00389-2-Biotin, M00389-2-Cy3, M00389-2-Dylight488, M00389-2-Dylight550, M00389-2-Dylight594, M00389-2-FITC, M00389-2-HRP, M00389-2-APC, M00389-2-PE, M00389-2-iFluor647, M00389-2-carrier-free
Alternative Names	CD46 molecule, complement regulatory protein
Background	Hepatocyte nuclear factor 4 alpha (HNF4A), also known as NR2A1, is a nuclear receptor that in humans is encoded by the HNF4A gene. It is mapped to 20q13.12. HNF4A is a nuclear transcription factor that binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene plays a role in development of the liver, kidney, and intestines. HNF4A is required for the PXR and CAR-mediated transcriptional activation of CYP3A4. This gene also plays a pivotal role in the expression and synthesis of SHBG, an important glycoprotein made primarily in the liver, which in addition to lowering insulin-resistance also serves in reducing levels of free Oestrogen as-well as prolonging the half-life of Testosterone.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-HNF-4-alpha Antibody Picoband® (monoclonal, 6C8E9) catalog # M00389-2. Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Acts as a cofactor for complement factor I,a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during ferti
Host	Mouse
Immunogen Region	E.coli-derived human HNF-4-alpha recombinant protein (Position: Q164-I474). Human HNF-4-alpha shares 95% and 96% amino acid (aa) sequence identity with mouse and rat HNF-4-alpha, respectively.
Isotype	Mouse IgG2a
Molecular Weight	53 kDa
Reactivity	Human, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	AHUS2 antibody; Antigen defined by monoclonal antibody; TRA 2 10 antibody; Antigen identified by monoclonal antibody; TRA 2 10 antibody; CD46 antibody; CD46 antigen antibody; CD46 antigen complement regulatory protein antibody; CD46 molecule antibody; CD46 molecule complement regulatory protein antibody; Complement membrane cofactor protein antibody; MCP antibody; MCP_HUMAN antibody; Measles virus receptor antibody; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen) antibody; Membrane cofactor protein antibody; MGC26544 antibody;MIC10 antibody; TLX antibody; TRA2.10 antibody; Trophoblast leucocyte common antigen antibody; Trophoblast leukocyte common antigen antibody; Trophoblast lymphocyte cross reactive antigen antibody
Tissue Specificity	Expressed by all cells except erythrocytes.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P41235
Gene Id	3172
Gene Name	HNF4A
Clone No	Clone: 6C8E9
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC
Description	Weste blot, 0.25-0.5 ug/ml, Human, Rat<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Rat<br>

Reference	1. Chartier FL, Bossu JP, Laudet V, Fruchart JC, Laine B (September 1994). "Cloning and sequencing of cDNAs encoding the human hepatocyte nuclear factor 4 indicate the presence of two isoforms in human liver". Gene 147 (2): 26972.<br /><br />2. Argyrokastritis A, Kamakari S, Kapsetaki M, Kritis A, Talianidis I, Moschonas NK (February 1997). "Human hepatocyte nuclear factor-4 (hHNF-4) gene maps to 20q12-q13.1 between PLCG1 and D20S17". Hum. Genet. 99 (2): 2336.<br /><br />3. Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, Duncan SA, Inoue Y, Gonzalez FJ, Schuetz EG, Kim RB (February 2003). "The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4". Nat. Med. 9 (2): 2204.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004159-1	M00389-2	-	100 ug	$370		Add to Cart
BHA21004159-2	M00389-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21004159-3	M00389-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004159-4	M00389-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004159-5	M00389-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004159-6	M00389-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004159-7	M00389-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004159-8	M00389-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21004159-9	M00389-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21004159-10	M00389-2-APC	APC	100 ug	$670		Add to Cart
BHA21004159-11	M00389-2-PE	PE	100 ug	$670		Add to Cart
BHA21004159-12	M00389-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004159-13	M00389-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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