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Home / Primary Antibodies / Monoclonal Antibodies

Anti-HGS Antibody Picoband® (monoclonal, 4B7E2)

SKU : BHA21004086

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Mfr.No.	M01174-2, M01174-2-10ug, M01174-2-Biotin, M01174-2-Cy3, M01174-2-Dylight488, M01174-2-Dylight550, M01174-2-Dylight594, M01174-2-FITC, M01174-2-HRP, M01174-2-APC, M01174-2-PE, M01174-2-iFluor647, M01174-2-carrier-free
Alternative Names	BCL2 antagonist/killer 1
Background	Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene. It is mapped to 17q25.3. The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-HGS Antibody Picoband® (monoclonal, 4B7E2) catalog # M01174-2. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, includ
Host	Mouse
Immunogen Region	E.coli-derived human HGS recombinant protein (Position: R3-D777).
Isotype	Mouse IgG2a
Molecular Weight	110 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Bcl-2 homologous antagonist/killer; Apoptosis regulator BAK; Bcl-2-like protein 7; Bcl2-L-7; BAK1; BAK; BCL2L7; CDN1
Tissue Specificity	Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	O14964
Gene Id	9146
Gene Name	HGS
Clone No	Clone: 4B7E2
Subcellular Location	Mitochondrion outer membrane. Single-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human, Mouse<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Asao, H., Sasaki, Y., Arita, T., Tanaka, N., Endo, K., Kasai, H., Takeshita, T, Endo, Y., Fujita, T., Sugamura, K. Hrs is associated with STAM, a signal-transducing adaptor molecule: its suppressive effect on cytokine-induced cell growth. J. Biol. Chem. 272: 32785-32791, 1997.<br /><br />2. Gutmann, D. H., Haipek, C. A., Burke, S. P., Sun, C.-X., Scoles, D. R., Pulst, S. M. The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the 'open' conformation and suppresses cell growth and motility. Hum. Molec. Genet. 10: 825-834, 2001.<br /><br />3. Komada, M., Masaki, R., Yamamoto, A., Kitamura, N. Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes. J. Biol. Chem. 272: 20538-20544, 1997.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004086-1	M01174-2	-	100 ug	$370		Add to Cart
BHA21004086-2	M01174-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21004086-3	M01174-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004086-4	M01174-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004086-5	M01174-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004086-6	M01174-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004086-7	M01174-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004086-8	M01174-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21004086-9	M01174-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21004086-10	M01174-2-APC	APC	100 ug	$670		Add to Cart
BHA21004086-11	M01174-2-PE	PE	100 ug	$670		Add to Cart
BHA21004086-12	M01174-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004086-13	M01174-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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