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Home / Primary Antibodies / Monoclonal Antibodies

Anti-GSTM1 Antibody Picoband® (monoclonal, 11F2)

SKU : BHA21001825

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Mfr.No.	M00569, M00569-10ug, M00569-Biotin, M00569-Cy3, M00569-Dylight488, M00569-Dylight550, M00569-Dylight594, M00569-FITC, M00569-HRP, M00569-APC, M00569-PE, M00569-iFluor647, M00569-carrier-free
Alternative Names	glutathione S-transferase mu 1
Background	Glutathione S-transferase Mu 1 (gene name GSTM1) is a human glutathione S-transferase. Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-GSTM1 Antibody Picoband® (monoclonal, 11F2) catalog # M00569. Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Host	Mouse
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human GSTM1, which shares 70.6% and 73.5% amino acid (aa) sequence identity with mouse and rat GSTM1, respectively.
Isotype	Mouse IgG1
Molecular Weight	26 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Glutathione S-transferase Mu 1; GST HB subunit 4; GST class-mu 1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4; GSTM1; GST1
Tissue Specificity	Liver (at protein level).
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P09488
Gene Id	2944
Gene Name	GSTM1
Clone No	Clone: 11F2
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> Immunohistochemistry (Frozen Section), 0.5-1ug/ml<br> Immunocytochemistry, 0.5-1ug/ml<br> Flow Cytometry (Fixed), 1-3ug/1x106 cells<br>

Reference	1. Carless, M. A., Lea, R. A., Curran, J. E., Appleyard, B., Gaffney, P., Green, A., Griffiths, L. R. TheGSTM1 null genotype confers an increased risk for solar keratosis development in an Australian Caucasian population. J. Invest. Derm. 119: 1373-1378, 2002. <br /><br />2. Zhong, S., Wyllie, A. H., Baes, D., Wolf, C. R., Spurr, N. K. Relationship between theGSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer.Carcinogenesis 14: 1821-1824, 1993.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001825-1	M00569	100 ug	-	$370		Add to Cart
BHA21001825-2	M00569-10ug	10 ug	Sample	$99		Add to Cart
BHA21001825-3	M00569-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001825-4	M00569-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001825-5	M00569-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001825-6	M00569-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001825-7	M00569-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001825-8	M00569-FITC	100 ug	FITC	$570		Add to Cart
BHA21001825-9	M00569-HRP	100 ug	HRP	$570		Add to Cart
BHA21001825-10	M00569-APC	100 ug	APC	$670		Add to Cart
BHA21001825-11	M00569-PE	100 ug	PE	$670		Add to Cart
BHA21001825-12	M00569-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001825-13	M00569-carrier-free	100 ug	carrier-free	$370		Add to Cart

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