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Home / Primary Antibodies / Monoclonal Antibodies

Anti-GNAQ Antibody Picoband® (monoclonal, 13H4)

SKU : BHA21002109

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Mfr.No.	M00898, M00898-10ug, M00898-Biotin, M00898-Cy3, M00898-Dylight488, M00898-Dylight550, M00898-Dylight594, M00898-FITC, M00898-HRP, M00898-APC, M00898-PE, M00898-iFluor647, M00898-carrier-free
Alternative Names	guanine nucleotide binding protein (G protein), q polypeptide
Background	Guanine nucleotide-binding protein G (q) subunit alpha is a protein that in humans is encoded by the GNAQ gene. Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GDP for GTP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit. G-alpha-q is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta. Mutations in this gene have been found associated to cases of Sturge-Weber syndrome and port-wine stains.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-GNAQ Antibody Picoband® (monoclonal, 13H4) catalog # M00898. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis o
Host	Mouse
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human GNAQ, identical to the related mouse and rat sequences.
Isotype	Mouse IgG2b
Molecular Weight	42 kDa
Reactivity	Human, Monkey, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Guanine nucleotide-binding protein G (q) subunit alpha; Guanine nucleotide-binding protein alpha-q; GNAQ; GAQ
Tissue Specificity	Predominantly expressed in ovary, prostate, testis and colon. Down-regulated in the peripheral blood lymphocytes (PBLs) of rheumatoid arthritis patients.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P50148
Gene Id	2776
Gene Name	GNAQ
Clone No	Clone: 13H4
Subcellular Location	Nucleus. Nucleus membrane. Membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, Flow Cytometry
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells<br>

Reference	1. Dong Q, Shenker A, Way J, Haddad BR, Lin K, Hughes MR, McBride OW, Spiegel AM, Battey J (February 1997). "Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene".Genomics 30 (3): 47075.<br /><br />2. Shirley MD, Tang H, Gallione CJ, Baugher JD, Frelin LP, Cohen B, North PE, Marchuk DA, Comi AM, Pevsner J (May 23, 2013). "Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ.". The New England Joual of Medicine368 (21): 19719.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002109-1	M00898	-	100 ug	$370		Add to Cart
BHA21002109-2	M00898-10ug	Sample	10 ug	$99		Add to Cart
BHA21002109-3	M00898-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002109-4	M00898-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002109-5	M00898-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002109-6	M00898-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002109-7	M00898-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002109-8	M00898-FITC	FITC	100 ug	$570		Add to Cart
BHA21002109-9	M00898-HRP	HRP	100 ug	$570		Add to Cart
BHA21002109-10	M00898-APC	APC	100 ug	$670		Add to Cart
BHA21002109-11	M00898-PE	PE	100 ug	$670		Add to Cart
BHA21002109-12	M00898-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002109-13	M00898-carrier-free	carrier-free	100 ug	$370		Add to Cart

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