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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Glycine decarboxylase/GLDC Antibody Picoband® (monoclonal, 3D3D3)

SKU : BHA21004295

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Mfr.No.	M04777, M04777-10ug, M04777-Biotin, M04777-Cy3, M04777-Dylight488, M04777-Dylight550, M04777-Dylight594, M04777-FITC, M04777-HRP, M04777-APC, M04777-PE, M04777-iFluor647, M04777-carrier-free
Alternative Names	cofilin 2
Background	Glycine decarboxylase also known as glycine cleavage system P protein or glycine dehydrogenase is an enzyme that in humans is encoded by the GLDC gene. Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Glycine decarboxylase/GLDC Antibody Picoband® (monoclonal, 3D3D3) catalog # M04777. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the m
Host	Mouse
Immunogen Region	E.coli-derived human Glycine decarboxylase/GLDC recombinant protein (Position: K574-S1020).
Isotype	Mouse IgG1
Molecular Weight	113 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Cofilin-2; Cofilin, muscle isoform; CFL2
Tissue Specificity	Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P23378
Gene Id	2731
Gene Name	GLDC
Clone No	Clone: 3D3D3
Subcellular Location	Cytoskeleton. Nucleus matrix.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human<br>

Reference	1. Alfi, O., Donnell, G. N., Allerdice, P. W., Derencesenyi, A. The 9p- syndrome. Ann. Genet. 19: 11-16, 1976.<br /><br />2. Applegarth, D. A., Toone, J. R. Nonketotic hyperglycinemia (glycine encephalopathy): laboratory diagnosis. Molec. Genet. Metab. 74: 139-146, 2001. <br /><br />3. Bodkin, J. A., Coleman, M. J., Godfrey, L. J., Carvalho, C. M. B., Morgan, C. J., Suckow, R. F., Anderson, T., Ongur, D., Kaufman, M. J., Lewandowski, K. E., Siegel, A. J., Waldstreicher, E., and 19 others. Targeted treatment of individuals with psychosis carrying a copy number variant containing a genomic triplication of the glycine decarboxylase gene. Biol. Psychiat. 86: 523-535, 2019.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004295-1	M04777	-	100 ug	$370		Add to Cart
BHA21004295-2	M04777-10ug	Sample	10 ug	$99		Add to Cart
BHA21004295-3	M04777-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004295-4	M04777-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004295-5	M04777-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004295-6	M04777-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004295-7	M04777-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004295-8	M04777-FITC	FITC	100 ug	$570		Add to Cart
BHA21004295-9	M04777-HRP	HRP	100 ug	$570		Add to Cart
BHA21004295-10	M04777-APC	APC	100 ug	$670		Add to Cart
BHA21004295-11	M04777-PE	PE	100 ug	$670		Add to Cart
BHA21004295-12	M04777-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004295-13	M04777-carrier-free	carrier-free	100 ug	$370		Add to Cart

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