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Home / Primary Antibodies / Monoclonal Antibodies

Anti-gamma Catenin Antibody Picoband® (monoclonal, 4C12D7)

SKU : BHA21004437

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Mfr.No.	M01901-3, M01901-3-10ug, M01901-3-Biotin, M01901-3-Cy3, M01901-3-Dylight488, M01901-3-Dylight550, M01901-3-Dylight594, M01901-3-FITC, M01901-3-HRP, M01901-3-APC, M01901-3-PE, M01901-3-iFluor647, M01901-3-carrier-free
Alternative Names	RAB5A, member RAS oncogene family
Background	Junction plakoglobin(JUP), also known as gamma-catenin, is a protein that in humans is encoded by the JUP gene. It is a member of the catenin protein family and homologous to beta-catenin, and it is mapped to 17q21.2. This gene encodes a major cytoplasmic protein that is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins. Meanwhile, JUP may have distinct roles in Wnt signaling and cancer via differential effects on downstream target genes.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-gamma Catenin Antibody Picoband® (monoclonal, 4C12D7) catalog # M01901-3. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to
Host	Mouse
Immunogen Region	E.coli-derived human gamma Catenin recombinant protein (Position: M556-A745). Human gamma Catenin shares 98% amino acid (aa) sequence identity with both mouse and rat gamma Catenin.
Isotype	Mouse IgG1
Molecular Weight	82 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Ras-related protein Rab-5A; RAB5A; RAB5
Tissue Specificity	Widely expressed in fetal and adult tissues.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P14923
Gene Id	3728
Gene Name	JUP
Clone No	Clone: 4C12D7
Subcellular Location	Early endosome membrane. Lipid-anchor. Endosome membrane. Cytosol. Cell membrane. Cytoplasmic side. Melanosome. Cytoplasmic vesicle. Ruffle. Membrane. Phagosome membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC, ICC, IF, Flow Cytometry
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Kolligs, F. T.; Kolligs, B.; Hajra, K. M.; Hu, G.; Tani, M.; Cho, K. R.; Fearon, E. R. : Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin. Genes Dev. 14: 1319-1331, 2000.<br /><br />2. "Entrez Gene: JUP junction plakoglobin"

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004437-1	M01901-3	-	100 ug	$370		Add to Cart
BHA21004437-2	M01901-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21004437-3	M01901-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004437-4	M01901-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004437-5	M01901-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004437-6	M01901-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004437-7	M01901-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004437-8	M01901-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21004437-9	M01901-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21004437-10	M01901-3-APC	APC	100 ug	$670		Add to Cart
BHA21004437-11	M01901-3-PE	PE	100 ug	$670		Add to Cart
BHA21004437-12	M01901-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004437-13	M01901-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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