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Home / Primary Antibodies / Monoclonal Antibodies

Anti-FHIT Antibody Picoband® (monoclonal, 26H7)

SKU : BHA21001756

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Mfr.No.	M01200, M01200-10ug, M01200-Biotin, M01200-Cy3, M01200-Dylight488, M01200-Dylight550, M01200-Dylight594, M01200-FITC, M01200-HRP, M01200-APC, M01200-PE, M01200-iFluor647, M01200-carrier-free
Alternative Names	fragile histidine triad
Background	Bis (5'-adenosyl)-triphosphatase, also known as fragile histidine triad protein (FHIT) is an enzyme that in humans is encoded by the FHIT gene. This gene, a member of the histidine triad gene family, encodes a diadenosine P1,P3-bis (5'-adenosyl)-triphosphate adenylohydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3p14.2, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Furthermore, FHIT has been shown to synergize with VHL, another tumor suppressor, in protecting against chemically - induced lung cancer. It also acts as a tumor suppressor of HER2/neu driven breast cancer.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-FHIT Antibody Picoband® (monoclonal, 26H7) catalog # M01200. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cleaves P (1)-P (3)-bis (5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P (1)-P (4)-bis (5'- adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby co
Host	Mouse
Immunogen Region	E.coli-derived human FHIT recombinant protein (Position: M1-Q147). Human FHIT shares 90% and 87% amino acid (aa) sequence identity with mouse and rat FHIT, respectively.
Isotype	Mouse IgG1
Molecular Weight	17 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Bis (5'-adenosyl)-triphosphatase; AP3A hydrolase; AP3Aase; Diadenosine 5',5'''-P1,P3-triphosphate hydrolase; Dinucleosidetriphosphatase; Fragile histidine triad protein; FHIT
Tissue Specificity	Low levels expressed in all tissues tested. Phospho-FHIT observed in liver and kidney, but not in brain and lung. Phospho-FHIT undetected in all tested human tumor cell lines.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P49789
Gene Id	2272
Gene Name	FHIT
Clone No	Clone: 26H7
Subcellular Location	Cytoplasm. Mitochondrion. Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunocytochemistry/Immunofluorescence, 2ug/ml<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells<br>

Reference	1. Ohta M, Inoue H, Cotticelli MG, Kastury K, Baffa R, Palazzo J, Siprashvili Z, Mori M, McCue P, Druck T, Croce CM, Huebner K (Apr 1996). "The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers". Cell 84 (4): 58797.<br /><br />2. Pekarsky Y, Campiglio M, Siprashvili Z, Druck T, Sedkov Y, Tillib S, Draganescu A, Wermuth P, Rothman JH, Huebner K, Buchberg AM, Mazo A, Brenner C, Croce CM (Aug 1998). "Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans". Proc Natl Acad Sci U S A 95 (15): 87449.<br /><br />3. Pollard KS, Salama SR, Lambert N, Lambot MA, Coppens S, Pedersen JS, Katzman S, King B, Onodera C, Siepel A, Ke AD, Dehay C, Igel H, Ares M Jr, Vanderhaeghen P, Haussler D (2006-08-16). "An RNA gene expressed during cortical development evolved rapidly in humans". Nature 443 (7108): 167172.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001756-1	M01200	100 ug	-	$370		Add to Cart
BHA21001756-2	M01200-10ug	10 ug	Sample	$99		Add to Cart
BHA21001756-3	M01200-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001756-4	M01200-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001756-5	M01200-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001756-6	M01200-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001756-7	M01200-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001756-8	M01200-FITC	100 ug	FITC	$570		Add to Cart
BHA21001756-9	M01200-HRP	100 ug	HRP	$570		Add to Cart
BHA21001756-10	M01200-APC	100 ug	APC	$670		Add to Cart
BHA21001756-11	M01200-PE	100 ug	PE	$670		Add to Cart
BHA21001756-12	M01200-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001756-13	M01200-carrier-free	100 ug	carrier-free	$370		Add to Cart

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