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Home / Primary Antibodies / Monoclonal Antibodies

Anti-FEN1 Antibody Picoband® (monoclonal, 7D11D7)

SKU : BHA21004081

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Mfr.No.	M01484-4, M01484-4-10ug, M01484-4-Biotin, M01484-4-Cy3, M01484-4-Dylight488, M01484-4-Dylight550, M01484-4-Dylight594, M01484-4-FITC, M01484-4-HRP, M01484-4-APC, M01484-4-PE, M01484-4-iFluor647, M01484-4-carrier-free
Alternative Names	keratin 8
Background	Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene. It is mapped to 11q12.2. The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-FEN1 Antibody Picoband® (monoclonal, 7D11D7) catalog # M01484-4. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Host	Mouse
Immunogen Region	E.coli-derived human FEN1 recombinant protein (Position: Q4-E300).
Isotype	Mouse IgG2b
Molecular Weight	48 kDa
Reactivity	Human, Mouse
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Keratin, type II cytoskeletal 8; Cytokeratin-8; CK-8; K8; Type-II keratin Kb8; KRT8; CYK8
Tissue Specificity	Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P39748
Gene Id	2237
Gene Name	FEN1
Clone No	Clone: 7D11D7
Subcellular Location	Nucleoplasm. Nucleus matrix. Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC, ICC, IF, Flow Cytometry
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Hiraoka LR, Harrington JJ, Gerhard DS, Lieber MR, Hsieh CL (Jul 1995). "Sequence of human FEN-1, a structure-specific endonuclease, and chromosomal localization of the gene (FEN1) in mouse and human". Genomics. 25 (1): 2205. <br /><br />2. Dianova II, Bohr VA, Dianov GL (Oct 2001). "Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair". Biochemistry. 40 (42): 1263944. <br /><br />3. Sharma S, Sommers JA, Wu L, Bohr VA, Hickson ID, Brosh RM (Mar 2004). "Stimulation of flap endonuclease-1 by the Bloom's syndrome protein". J. Biol. Chem. 279 (11): 984756.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004081-1	M01484-4	-	100 ug	$370		Add to Cart
BHA21004081-2	M01484-4-10ug	Sample	10 ug	$99		Add to Cart
BHA21004081-3	M01484-4-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004081-4	M01484-4-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004081-5	M01484-4-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004081-6	M01484-4-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004081-7	M01484-4-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004081-8	M01484-4-FITC	FITC	100 ug	$570		Add to Cart
BHA21004081-9	M01484-4-HRP	HRP	100 ug	$570		Add to Cart
BHA21004081-10	M01484-4-APC	APC	100 ug	$670		Add to Cart
BHA21004081-11	M01484-4-PE	PE	100 ug	$670		Add to Cart
BHA21004081-12	M01484-4-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004081-13	M01484-4-carrier-free	carrier-free	100 ug	$370		Add to Cart

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