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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Elafin/Skalp PI3 Antibody (monoclonal, C7)

SKU : BHA21001758

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Mfr.No.	M00364, M00364-10ug, M00364-Biotin, M00364-Cy3, M00364-Dylight488, M00364-Dylight550, M00364-Dylight594, M00364-FITC, M00364-HRP, M00364-APC, M00364-PE, M00364-iFluor647, M00364-carrier-free
Alternative Names	peptidase inhibitor 3
Background	Elafin, also known as peptidase inhibitor 3 or skin-derived antileukoprotease (SKALP), is a protein that in humans is encoded by the PI3 gene. This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. And this gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Elafin/Skalp PI3 Antibody Picoband® (monoclonal, C7) catalog # M00364. Tested in ELISA, IHC applications. This antibody reacts with Human.
Function	Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.
Host	Mouse
Immunogen Region	E. coli-derived human Elafin/Skalp recombinant protein (Position: A61-Q117).
Isotype	Mouse IgG1
Molecular Weight	25 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Elafin; Elastase-specific inhibitor; ESI; Peptidase inhibitor 3; PI-3; Protease inhibitor WAP3; Skin-derived antileukoproteinase; SKALP; WAP four-disulfide core domain protein 14; PI3; WAP3; WFDC14
Tissue Specificity	Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P19957
Gene Id	5266
Gene Name	PI3
Clone No	Clone: C7
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IHC
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> ELISA (Cap), 1-5ug/ml

Reference	1. "Entrez Gene: PI3 peptidase inhibitor 3, skin-derived (SKALP)".<br /><br />2. Clauss A, Lilja H, Lundwall A (Nov 2002). "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein". Biochem J 368 (Pt 1): 23342.<br /><br />3. Molhuizen HO, Zeeuwen PL, Olde Weghuis D, Geurts van Kessel A, Schalkwijk J (Feb 1994). "Assignment of the human gene encoding the epidermal serine proteinase inhibitor SKALP (PI3) to chromosome region 20q12?q13". Cytogenet Cell Genet 66 (2): 12931.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001758-1	M00364	100 ug	-	$370		Add to Cart
BHA21001758-2	M00364-10ug	10 ug	Sample	$99		Add to Cart
BHA21001758-3	M00364-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001758-4	M00364-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001758-5	M00364-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001758-6	M00364-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001758-7	M00364-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001758-8	M00364-FITC	100 ug	FITC	$570		Add to Cart
BHA21001758-9	M00364-HRP	100 ug	HRP	$570		Add to Cart
BHA21001758-10	M00364-APC	100 ug	APC	$670		Add to Cart
BHA21001758-11	M00364-PE	100 ug	PE	$670		Add to Cart
BHA21001758-12	M00364-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001758-13	M00364-carrier-free	100 ug	carrier-free	$370		Add to Cart

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