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Home / Primary Antibodies / Monoclonal Antibodies

Anti-EIF6 Antibody Picoband® (monoclonal, 2I11)

SKU : BHA21002108

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Mfr.No.	M03581, M03581-10ug, M03581-Biotin, M03581-Cy3, M03581-Dylight488, M03581-Dylight550, M03581-Dylight594, M03581-FITC, M03581-HRP, M03581-APC, M03581-PE, M03581-iFluor647, M03581-carrier-free
Alternative Names	eukaryotic translation initiation factor 6
Background	EIF6 (Eukaryotic Translation Initiation Factor 6), also called EIF3A or ITGB4BP, is a human gene. By fluorescence in situ hybridization, Sanvito et al. (1998) mapped the ITGB4BP gene to 20q11.2. Ceci et al. (2003) demonstrated that the ribosomal 60S subunit is activated by release of EIF6. In the cytoplasm, EIF6 is bound to free 60S but not to 80S subunits. Furthermore, EIF6 interacts in the cytoplasm with RACK1, a receptor for activated protein kinase C. Gandin et al. (2008) demonstrated that mammalian eIF6 is required for efficient initiation of translation in vivo. Eif6-null mouse embryos were lethal at preimplantation. Heterozygous mice had 50% reduction of eIF6 levels in all tissues, and showed reduced mass of hepatic and adipose tissues due to a lower number of cells and to impaired G1/S cell cycle progression.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-EIF6 Antibody Picoband® (monoclonal, 2I11) catalog # M03581. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved
Host	Mouse
Immunogen Region	E.coli-derived human EIF6 recombinant protein (Position: N66-T210). Human EIF6 shares 99.3% amino acid (aa) sequence identity with both mouse and rat EIF6.
Isotype	Mouse IgG2a
Molecular Weight	26 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Eukaryotic translation initiation factor 6; eIF-6; B (2)GCN homolog; B4 integrin interactor; CAB; p27 (BBP); EIF6; EIF3A; ITGB4BP; OK/SW-cl.27
Tissue Specificity	Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P56537
Gene Id	3992
Gene Name	EIF6
Clone No	Clone: 2I11
Subcellular Location	nucleolus. Cytoplasm

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, Flow Cytometry
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells<br>

Reference	1. Ceci, M., Gaviraghi, C., Gorrini, C., Sala, L. A., Offenhauser, N., Marchisio, P. C., Biffo, S. Release of eIF6 (p27-BBP) from the 60S subunit allows 80S ribosome assembly. Nature 426: 579-584, 2003. <br /><br />2. Gandin, V., Miluzio, A., Barbieri, A. M., Beugnet, A., Kiyokawa, H., Marchisio, P. C., Biffo, S. Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation. Nature 455: 684-688, 2008. <br /><br />3. Sanvito, F., Arrigo, G., Zuffardi, O., Agnelli, M., Marchisio, P. C., Biffo, S. Localization of p27 beta-4 binding protein gene (ITGB4BP) to human chromosome region 20q11.2. Genomics 52: 111-112, 1998.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002108-1	M03581	-	100 ug	$370		Add to Cart
BHA21002108-2	M03581-10ug	Sample	10 ug	$99		Add to Cart
BHA21002108-3	M03581-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002108-4	M03581-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002108-5	M03581-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002108-6	M03581-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002108-7	M03581-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002108-8	M03581-FITC	FITC	100 ug	$570		Add to Cart
BHA21002108-9	M03581-HRP	HRP	100 ug	$570		Add to Cart
BHA21002108-10	M03581-APC	APC	100 ug	$670		Add to Cart
BHA21002108-11	M03581-PE	PE	100 ug	$670		Add to Cart
BHA21002108-12	M03581-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002108-13	M03581-carrier-free	carrier-free	100 ug	$370		Add to Cart

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