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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Drebrin/DBN1 Antibody Picoband® (monoclonal, 4F6E7)

SKU : BHA21004276

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Mfr.No.	M05530-4, M05530-4-10ug, M05530-4-Biotin, M05530-4-Cy3, M05530-4-Dylight488, M05530-4-Dylight550, M05530-4-Dylight594, M05530-4-FITC, M05530-4-HRP, M05530-4-APC, M05530-4-PE, M05530-4-iFluor647, M05530-4-carrier-free
Alternative Names	cytochrome c oxidase subunit 4I1
Background	Drebrin is a protein that in humans is encoded by the DBN1 gene. The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alteative splice variants encoding different protein isoforms have been described for this gene.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Drebrin/DBN1 Antibody Picoband® (monoclonal, 4F6E7) catalog # M05530-4. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Host	Mouse
Immunogen Region	E.coli-derived human Drebrin/DBN1 recombinant protein (Position: H9-D649).
Isotype	Mouse IgG2a
Molecular Weight	120 kDa
Reactivity	Human, Mouse, Rat, Monkey
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; Cytochrome c oxidase polypeptide IV; Cytochrome c oxidase subunit IV isoform 1; COX IV-1; COX4I1; COX4
Tissue Specificity	Highly expressed in liver. Expressed in testis and weakly in colon.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q16643
Gene Id	1627
Gene Name	DBN1
Clone No	Clone: 4F6E7
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC, Flow Cytometry
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat, Monkey<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human, Rat<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Akbar, M., Kim, H. Y. Protective effects of docosahexaenoic acid in staurosporine-induced apoptosis: involvement of phosphatidylinositol-3 kinase pathway. J. Neurochem. 82: 655-665, <br /><br />2. Calon, F., Lim, G. P., Yang, F., Morihara, T., Teter, B., Ubeda, O., Rostaing, P., Triller, A., Salem, N., Jr., Ashe, K. H., Frautschy, S. A., Cole, G. M. Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron 43: 633-645, 2004. <br /><br />3. Harigaya, Y., Shoji, M., Shirao, T., Hirai, S. Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease. J. Neurosci. Res. 43: 87-92, 1996.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004276-1	M05530-4	-	100 ug	$370		Add to Cart
BHA21004276-2	M05530-4-10ug	Sample	10 ug	$99		Add to Cart
BHA21004276-3	M05530-4-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004276-4	M05530-4-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004276-5	M05530-4-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004276-6	M05530-4-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004276-7	M05530-4-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004276-8	M05530-4-FITC	FITC	100 ug	$570		Add to Cart
BHA21004276-9	M05530-4-HRP	HRP	100 ug	$570		Add to Cart
BHA21004276-10	M05530-4-APC	APC	100 ug	$670		Add to Cart
BHA21004276-11	M05530-4-PE	PE	100 ug	$670		Add to Cart
BHA21004276-12	M05530-4-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004276-13	M05530-4-carrier-free	carrier-free	100 ug	$370		Add to Cart

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