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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Desmoglein 2/DSG2 Antibody Picoband® (monoclonal, 2B4D1)

SKU : BHA21004827

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Mfr.No.	M02035-2, M02035-2-10ug, M02035-2-Biotin, M02035-2-Cy3, M02035-2-Dylight488, M02035-2-Dylight550, M02035-2-Dylight594, M02035-2-FITC, M02035-2-HRP, M02035-2-APC, M02035-2-PE, M02035-2-iFluor647, M02035-2-carrier-free
Alternative Names	desmin
Background	Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in DSG2 display a high degree of penetrance. Disease expression was of variable severity with LV involvement a prominent feature. The low prevalence of classical ECG changes highlights the need to expand current diagnostic criteria to take account of LV disease, childhood disease expression, and incomplete penetrance.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Desmoglein 2/DSG2 Antibody Picoband® (monoclonal, 2B4D1) catalog # M02035-2. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sar
Host	Mouse
Immunogen Region	E.coli-derived human Desmoglein 2/DSG2 recombinant protein (Position: L24-E1020).
Isotype	IgG1
Molecular Weight	160 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Desmin; DES
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q14126
Gene Id	1829
Gene Name	DSG2
Clone No	Clone: 2B4D1
Subcellular Location	Nucleus. Sarcolemma. Z line. Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB, IHC
Description	Weste blot, 0.25-0.5 ug/ml, Human Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human

Reference	1. Aemann J, Spurr NK, Magee AI, Buxton RS (Jul 1992). "The human gene (DSG2) coding for HDGC, a second member of the desmoglein subfamily of the desmosomal cadherins, is, like DSG1 coding for desmoglein DGI, assigned to chromosome 18". Genomics 13 (2): 4846. 2. "Entrez Gene: DSG2 desmoglein 2". mutations in DSG2 contribute to the development of ARVD/C. 3. Syrris, P., Ward, D., Asimaki, A., Evans, A., Sen-Chowdhry, S., Hughes, S. E., McKenna, W. J. Desmoglein-2 mutations in arrhythmogenic right ventricular cardiomyopathy: a genotype-phenotype characterization of familial disease. Europ. Heart J. 28: 581-588, 2007.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004827-1	M02035-2	-	100 ug	$370		Add to Cart
BHA21004827-2	M02035-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21004827-3	M02035-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004827-4	M02035-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004827-5	M02035-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004827-6	M02035-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004827-7	M02035-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004827-8	M02035-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21004827-9	M02035-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21004827-10	M02035-2-APC	APC	100 ug	$670		Add to Cart
BHA21004827-11	M02035-2-PE	PE	100 ug	$670		Add to Cart
BHA21004827-12	M02035-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004827-13	M02035-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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