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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Cyclin T1 Antibody Picoband® (monoclonal, 3B7)

SKU : BHA21003505

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Mfr.No.	M02703, M02703-10ug, M02703-Biotin, M02703-Cy3, M02703-Dylight488, M02703-Dylight550, M02703-Dylight594, M02703-FITC, M02703-HRP, M02703-APC, M02703-PE, M02703-iFluor647, M02703-carrier-free
Alternative Names	retinoblastoma binding protein 4
Background	Cyclin-T1 is a protein that in humans is encoded by the CCNT1 gene. This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alteative splicing results in multiple transcript variants.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Cyclin T1 Antibody Picoband® (monoclonal, 3B7) catalog # M02703. Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chro
Host	Mouse
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human Cyclin T1, different from the related mouse sequence by one amino acid.
Isotype	Mouse IgG2b
Molecular Weight	81 kDa
Reactivity	Human, Monkey
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Histone-binding protein RBBP4; Chromatin assembly factor 1 subunit C; CAF-1 subunit C; Chromatin assembly factor I p48 subunit; CAF-I 48 kDa subunit; CAF-I p48; Nucleosome-remodeling factor subunit RBAP48; Retinoblastoma-binding protein 4; RBBP-4; Retinoblastoma-binding protein p48; RBBP4; RBAP48
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	O60563
Gene Id	904
Gene Name	CCNT1
Clone No	Clone: 3B7
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, Flow Cytometry
Description	Weste blot, 0.25-0.5 ug/ml, Human, Monkey Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human

Reference	1. "Entrez Gene: CCNT1 cyclin T1". 2. Peng J, Zhu Y, Milton JT, Price DH (April 1998). "Identification of multiple cyclin subunits of human P-TEFb". Genes Dev. 12 (5): 75562. 3. Wei P, Garber ME, Fang SM, Fischer WH, Jones KA (March 1998). "A novel CDK9-associated C-type cyclin interacts ly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA". Cell92 (4): 45162.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003505-1	M02703	-	100 ug	$370		Add to Cart
BHA21003505-2	M02703-10ug	Sample	10 ug	$99		Add to Cart
BHA21003505-3	M02703-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003505-4	M02703-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003505-5	M02703-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003505-6	M02703-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003505-7	M02703-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003505-8	M02703-FITC	FITC	100 ug	$570		Add to Cart
BHA21003505-9	M02703-HRP	HRP	100 ug	$570		Add to Cart
BHA21003505-10	M02703-APC	APC	100 ug	$670		Add to Cart
BHA21003505-11	M02703-PE	PE	100 ug	$670		Add to Cart
BHA21003505-12	M02703-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003505-13	M02703-carrier-free	carrier-free	100 ug	$370		Add to Cart

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