Neutralizing recombinant human monoclonal antibody recognizing the extracellular domain of CTLA4 and blocking binding of CTLA4 to B7.1 and B7.2. This antibody recognizes human CTLA4 but does not bind to murine CTLA4. This antibody has not been tested for cross-reactivity with other species.
assay conditions: Antibody was added toCTLA4:B7.1 binding assay at variousconcentrations. Assay was done according toBPS Cat. #72009 protocol.
Endotoxin level < 1 EU/ ug.
Specific activity: IC50 = 5 nM
Formulation
8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, pH 7.4, and 20% glycerol
Isotype
IgG1kappa
Species
Human
Synonyms
Cytotoxic T-lymphocyte-associated protein 4, CD152
Note
Avoid freeze/thaw cycles. Store diluted antibody with carrier protein (BSA 0.1 - 0.5%) at 4°C, stable for 2 weeks.
Uniprot
P16410
Format
Aqueous buffer solution.
Purification
Protein A affinity chromatographyfrom HEK293 supernatants.