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Home / Primary Antibodies / Monoclonal Antibodies

Anti-CDC45L Picoband® Antibody (monoclonal, 6H6)

SKU : BHA21003150

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Mfr.No.	M01367-2, M01367-2-10ug, M01367-2-Biotin, M01367-2-Cy3, M01367-2-Dylight488, M01367-2-Dylight550, M01367-2-Dylight594, M01367-2-FITC, M01367-2-HRP, M01367-2-APC, M01367-2-PE, M01367-2-iFluor647, M01367-2-carrier-free
Alternative Names	keratin 18
Background	CDC45 is a protein that in humans is encoded by the CDC45L gene. The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alteate splicing results in multiple transcript variants.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-CDC45L Picoband® Antibody (monoclonal, 6H6) catalog # M01367-2. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL
Host	Mouse
Immunogen Region	E. coli-derived human CDC45L recombinant protein (Position: E166-A431).
Isotype	Mouse IgG1
Molecular Weight	66 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Keratin, type I cytoskeletal 18; Cell proliferation-inducing gene 46 protein; Cytokeratin-18; CK-18; Keratin-18; K18; KRT18; CYK18; PIG46
Tissue Specificity	Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	O75419
Gene Id	8318
Gene Name	CDC45
Clone No	Clone: 6H6
Subcellular Location	Nucleolus. Perinuclear region.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, Flow Cytometry
Description	Weste blot, 0.25-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, Mouse, Rat<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. "Entrez Gene: CDC45L CDC45 cell division cycle 45-like (S. cerevisiae)".<br /><br />2. McKie JM, Wadey RB, Sutherland HF, Taylor CL, Scambler PJ (Sep 1998). " selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene". Genome Res. 8 (8): 83441.<br /><br />3. Saha P, Thome KC, Yamaguchi R, Hou Z, Weremowicz S, Dutta A (Aug 1998). "The human homolog of Saccharomyces cerevisiae CDC45". J. Biol. Chem. 273 (29): 182059.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003150-1	M01367-2	-	100 ug	$370		Add to Cart
BHA21003150-2	M01367-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003150-3	M01367-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003150-4	M01367-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003150-5	M01367-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003150-6	M01367-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003150-7	M01367-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003150-8	M01367-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003150-9	M01367-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003150-10	M01367-2-APC	APC	100 ug	$670		Add to Cart
BHA21003150-11	M01367-2-PE	PE	100 ug	$670		Add to Cart
BHA21003150-12	M01367-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003150-13	M01367-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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