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Home / Primary Antibodies / Monoclonal Antibodies

Anti-CD20-Anti-CD3 Bispecific Antibody

SKU : BHA18200050

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BPS Bioscience

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Mfr.No.	100836-1
Background	CD20 (MS4A1) is a glycosylated phosphoprotein expressed on the cell surface of B cells. Although the functional significance of CD20 is not clear, and CD20 has no known ligands, CD20 has been shown to regulate intracellular calcium levels. CD20 is a highly attractive target antigen for immunotherapy because it is expressed in more than 90% of patients with B-cell lymphoma. First approved in 1997, Rituximab (Rituxan) is a chimeric monoclonal antibody targeting CD20 and has been classified by the World Health Organization as an "Essential Medicine". Since then, additional monoclonal antibodies against CD20 have been approved or are being tested in clinical trials for the treatment of multiple sclerosis (MS), chronic lymphocytic leukemia (CLL), follicular lymphoma, diffuse large B cell lymphoma (DLBCL), rheumatoid arthritis, non-Hodgkin's lymphoma, systemic lupus erythematosus, and myalgic encephalomyelitis (chronic fatigue syndrome).
Clonality	Monoclonal (Bispecific)
Description	Anti-CD20-Anti-CD3 Fc format bispecific antibody is a purified recombinant human bispecific antibody with T cell Engager. This bispecific antibody has been tested for specific activity in the functional reporter assay using NFAT-luc reporter Jurkat cell line (BPS Bioscience #60621) in the presence of CD20-CHO cells (BPS Bioscience #79624-H).
Formulation	8 mM phosphate, 110 mM NaCl, 2.2 mM KCl, pH 7.4, and 20% glycerol
Species	Human
Synonyms	Bite, cd20 bite, Blinatumomab, bispecific antibody, cd3 bite, 100836-1, 100836-2
Note	Avoid freeze/thaw cycles.

Purification	Protein A affinity purification of Fc-tag protein from HEK293 cells
Shipping Temperature	-80°C (dry ice)
Storage Stability	Stable for at least 12 months at -80°C.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA18200050	100836-1	50 ug	$407		Add to Cart

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