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Home / Primary Antibodies / Monoclonal Antibodies

Anti-CD147/Emmprin Antibody Picoband® (monoclonal, 6H2B2)

SKU : BHA21004096

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Mfr.No.	M00248-6, M00248-6-10ug, M00248-6-Biotin, M00248-6-Cy3, M00248-6-Dylight488, M00248-6-Dylight550, M00248-6-Dylight594, M00248-6-FITC, M00248-6-HRP, M00248-6-APC, M00248-6-PE, M00248-6-iFluor647, M00248-6-carrier-free
Alternative Names	tuberous sclerosis 2
Background	Emmprin, extracellular matrix metalloproteinase inducer, also known as Emmprin (BSG) or cluster of differentiation 147 (CD147) is a protein that in humans is encoded by the Emmprin gene. The human BSG gene is mapped to 19p13.3. This protein is a determinant for the Ok blood group system. BSG has been shown to be an essential receptor on red blood cells for the malaria parasite. It is a member of the immunoglobulin superfamily, with a structure related to the putative primordial form of the family. As members of the immunoglobulin superfamily, it plays fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development. BSG is thought also to play a role in intercellular recognition. It also regulates several distinct functions, such as spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes. BSG is a type I integral membrane receptor that has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B and certain integrins. It is expressed by many cell types, including epithelial cells, endothelial cells and leukocytes.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-CD147/Emmprin Antibody Picoband® (monoclonal, 6H2B2) catalog # M00248-6. Tested in IF, IHC, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Acts as a GTPase-activating protein (
Host	Mouse
Immunogen Region	E.coli-derived human CD147/Emmprin recombinant protein (Position: E138-A323). Human CD147/Emmprin shares 51.1% and 51.9% amino acid (aa) sequence identity with mouse and rat CD147/Emmprin, respectively.
Isotype	Mouse IgG2b
Molecular Weight	35-60 kDa
Reactivity	Human, Mouse
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Tuberin; Tuberous sclerosis 2 protein; TSC2; TSC4
Tissue Specificity	Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P35613
Gene Id	682
Gene Name	BSG
Clone No	Clone: 6H2B2
Subcellular Location	Cytoplasm; Membrane; Peripheral membrane protein

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC, IF
Description	Weste blot, 0.25-0.5 ug/ml, Human<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human, Mouse<br> Immunocytochemistry, 5 ug/ml, Human<br>

Reference	1. Guo, H., Majmudar, G., Jensen, T. C., Biswas, C., Toole, B. P., Gordon, M. K.Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases.Gene 220: 99-108, 1998.<br /><br />2. Zhou, S., Zhou, H., Walian, P. J., Jap, B. K.CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004096-1	M00248-6	-	100 ug	$370		Add to Cart
BHA21004096-2	M00248-6-10ug	Sample	10 ug	$99		Add to Cart
BHA21004096-3	M00248-6-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004096-4	M00248-6-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004096-5	M00248-6-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004096-6	M00248-6-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004096-7	M00248-6-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004096-8	M00248-6-FITC	FITC	100 ug	$570		Add to Cart
BHA21004096-9	M00248-6-HRP	HRP	100 ug	$570		Add to Cart
BHA21004096-10	M00248-6-APC	APC	100 ug	$670		Add to Cart
BHA21004096-11	M00248-6-PE	PE	100 ug	$670		Add to Cart
BHA21004096-12	M00248-6-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004096-13	M00248-6-carrier-free	carrier-free	100 ug	$370		Add to Cart

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