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Home / Primary Antibodies / Monoclonal Antibodies

Anti-CCR2 Antibody Picoband® (monoclonal, 8C4)

SKU : BHA21002591

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Mfr.No.	M00158-1, M00158-1-10ug, M00158-1-Biotin, M00158-1-Cy3, M00158-1-Dylight488, M00158-1-Dylight550, M00158-1-Dylight594, M00158-1-FITC, M00158-1-HRP, M00158-1-APC, M00158-1-PE, M00158-1-iFluor647, M00158-1-carrier-free
Alternative Names	C-C motif chemokine receptor 2
Background	C-C chemokine receptor type 2 (CCR2 or CD192 (cluster of differentiation 192) is a protein that in humans is encoded by the CCR2 gene. It is mapped to 3p21.31. The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-CCR2 Antibody Picoband® (monoclonal, 8C4) catalog # M00158-1. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Key functional receptor for CCL2 but can also bind CCL7 and CCL12. Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrus
Host	Mouse
Immunogen Region	E.coli-derived human CCR2 recombinant protein (Position: M1-F125).
Isotype	Mouse IgG2b
Molecular Weight	42 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; Monocyte chemoattractant protein 1 receptor; MCP-1-R; CD192; CCR2; CMKBR2
Tissue Specificity	Expressed by monocytes and IL2-activated NK cells.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	P41597
Gene Id	729230
Gene Name	CCR2
Clone No	Clone: 8C4
Subcellular Location	Cell membrane. Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 2ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Abbadie, C., Lindia, J. A., Cumiskey, A. M., Peterson, L. B., Mudgett, J. S., Bayne, E. K., DeMartino, J. A., MacIntyre, D. E., Forrest, M. J. Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. Proc. Nat. Acad. Sci. 100: 7947-7952, 2003. <br /><br />2. Peters, W., Dupuis, M., Charo, I. F. A mechanism for the impaired IFN-gamma production in C-C chemokine receptor 2 (CCR2) knockout mice: role of CCR2 in linking the innate and adaptive immune responses. J. Immun. 165: 7072-7077, 2000.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002591-1	M00158-1	-	100 ug	$370		Add to Cart
BHA21002591-2	M00158-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21002591-3	M00158-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002591-4	M00158-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002591-5	M00158-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002591-6	M00158-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002591-7	M00158-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002591-8	M00158-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21002591-9	M00158-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21002591-10	M00158-1-APC	APC	100 ug	$670		Add to Cart
BHA21002591-11	M00158-1-PE	PE	100 ug	$670		Add to Cart
BHA21002591-12	M00158-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002591-13	M00158-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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