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Home / Primary Antibodies / Monoclonal Antibodies

Anti-CBS Antibody Picoband® (monoclonal, 5B5D7)

SKU : BHA21004440

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Mfr.No.	M00130-3, M00130-3-10ug, M00130-3-Biotin, M00130-3-Cy3, M00130-3-Dylight488, M00130-3-Dylight550, M00130-3-Dylight594, M00130-3-FITC, M00130-3-HRP, M00130-3-APC, M00130-3-PE, M00130-3-iFluor647, M00130-3-carrier-free
Alternative Names	isocitrate dehydrogenase 1 (NADP+), soluble
Background	CBS, Cystathionine Beta-Synthase, catalyzes the first irreversible step of transsulfuration. The CBS enzyme is a homotetramer of 63-kD subunits and requires pyridoxal phosphate and heme for activity. The CBS gene, which is mapped to chromosome 21q22, contains 23 exons, ranging in size from 42 to 299 bp. The human CBS protein can substitute for the endogenous yeast CBS protein in Saccharomyces cerevisiae. The catalytic domain of the CBS protein is located in the N-terminal 409 amino acids, and a regulatory domain is located in the C-terminal 142 amino acids.A mutation that deletes the C-terminal 145 amino acids of CBS could restore activity of several CBS mutant alleles found in homocystinurics.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-CBS Antibody Picoband® (monoclonal, 5B5D7) catalog # M00130-3. Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on
Host	Mouse
Immunogen Region	E.coli-derived human CBS recombinant protein (Position: K102-E342).
Isotype	Mouse IgG1
Molecular Weight	61 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Cytosolic NADP isocitrate dehydrogenase antibody\|Cytosolic NADP-isocitrate dehydrogenase antibody\|Epididymis luminal protein 216 antibody\|Epididymis secretory protein Li 26 antibody\|HEL-216 antibody\|HEL-S-26 antibody\|ICDH antibody\|IDCD antibody\|IDH antibody\|IDH1 antibody\|IDHC_HUMAN antibody\|IDP antibody\|IDPC antibody\|Isocitrate dehydrogenase (NADP) cytoplasmic antibody\|Isocitrate dehydrogenase 1 (NADP+) soluble antibody\|NADP dependent isocitrate dehydrogenase cytosolic antibody\|NADP dependent isocitrate dehydrogenase peroxisomal antibody\|NADP (+)-specific ICDH antibody\|Oxalosuccinate decarboxylase antibody\|PICD antibody
Tissue Specificity	Ubiquituous. Expressed in platelets.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P35520
Gene Id	875
Gene Name	CBS
Clone No	Clone: 5B5D7
Subcellular Location	Cytoplasm. Peroxisome.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, Flow Cytometry
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Munke, M., Kraus, J., Watkins, P., Tanzi, R., Gusella, J., Millington Ward, A., Watson, M., Francke, U.Homocystinuria gene on human chromosome 21 mapped with cloned cystathionine beta-synthase probe and in situ hybridization of other chromosome 21 probes. (Abstract)Cytogenet. Cell Genet. 40: 706-707, 1985.<br /><br />2. Kraus, J. P., Oliveriusova, J., Sokolova, J., Kraus, E., Vlcek, C., de Franchis, R., Maclean, K. N., Bao, L., Bukovska, G., Patterson, D., Paces, V., Ansorge, W., Kozich, V.The human cystathionine beta-synthase (CBS) gene: complete sequence, alteative splicing, and polymorphisms.Genomics 52: 312-324, 1998.<br /><br />3. Kruger, W. D., Cox, D. R.A yeast system for expression of human cystathionine beta-synthase: structural and functional conservation of the human and yeast genes.Proc. Nat. Acad. Sci. 91: 6614-6618, 1994.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004440-1	M00130-3	-	100 ug	$370		Add to Cart
BHA21004440-2	M00130-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21004440-3	M00130-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004440-4	M00130-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004440-5	M00130-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004440-6	M00130-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004440-7	M00130-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004440-8	M00130-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21004440-9	M00130-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21004440-10	M00130-3-APC	APC	100 ug	$670		Add to Cart
BHA21004440-11	M00130-3-PE	PE	100 ug	$670		Add to Cart
BHA21004440-12	M00130-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004440-13	M00130-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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