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Home / Primary Antibodies / Monoclonal Antibodies

Anti-CASR Antibody Picoband® (monoclonal, 11E9)

SKU : BHA21001827

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Mfr.No.	M00574, M00574-10ug, M00574-Biotin, M00574-Cy3, M00574-Dylight488, M00574-Dylight550, M00574-Dylight594, M00574-FITC, M00574-HRP, M00574-APC, M00574-PE, M00574-iFluor647, M00574-carrier-free
Alternative Names	calcium sensing receptor
Background	The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-CASR Antibody Picoband® (monoclonal, 11E9) catalog # M00574. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, Pu
Host	Mouse
Immunogen Region	E. coli-derived human CASR recombinant protein (Position: Q926-S1078). Human CASR shares 80.5% and 78.6% amino acid (aa) sequence identity with mouse and rat CASR, respectively.
Isotype	Mouse IgG2b
Molecular Weight	130 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Extracellular calcium-sensing receptor; CaR
Tissue Specificity	Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Uniprot	P41180
Gene Id	846
Gene Name	CASR
Clone No	Clone: 11E9
Subcellular Location	Cell membrane

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml<br>

Reference	1. Cobu JW, Elangovan L, Goodman WG, Frazaõ JM (Dec 1999). "Calcium-sensing receptor and calcimimetic agents". Kidney Inteational. Supplement 73: S528.<br /><br />2. D'Souza-Li L (Aug 2006). "The calcium-sensing receptor and related diseases". Arquivos Brasileiros De Endocrinologia E Metabologia 50 (4): 62839.<br /><br />3. Pidasheva S, Canaff L, Simonds WF, Marx SJ, Hendy GN (Jun 2005). "Impaired cotranslational processing of the calcium-sensing receptor due to signal peptide missense mutations in familial hypocalciuric hypercalcemia". Human Molecular Genetics 14 (12): 167990.<br /><br />

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001827-1	M00574	100 ug	-	$370		Add to Cart
BHA21001827-2	M00574-10ug	10 ug	Sample	$99		Add to Cart
BHA21001827-3	M00574-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001827-4	M00574-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001827-5	M00574-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001827-6	M00574-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001827-7	M00574-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001827-8	M00574-FITC	100 ug	FITC	$570		Add to Cart
BHA21001827-9	M00574-HRP	100 ug	HRP	$570		Add to Cart
BHA21001827-10	M00574-APC	100 ug	APC	$670		Add to Cart
BHA21001827-11	M00574-PE	100 ug	PE	$670		Add to Cart
BHA21001827-12	M00574-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001827-13	M00574-carrier-free	100 ug	carrier-free	$370		Add to Cart

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