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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Beta 2 Microglobulin B2M Antibody Picoband® (monoclonal, 2H10)

SKU : BHA21002040

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Mfr.No.	M00456-2, M00456-2-10ug, M00456-2-Biotin, M00456-2-Cy3, M00456-2-Dylight488, M00456-2-Dylight550, M00456-2-Dylight594, M00456-2-FITC, M00456-2-HRP, M00456-2-APC, M00456-2-PE, M00456-2-iFluor647, M00456-2-carrier-free
Alternative Names	beta-2-microglobulin
Background	Beta-2 microglobulin also known as B2M is a component of MHC class I molecules, which are present on all nucleated cells (excludes red blood cells). In humans, the beta-2-microglobulin protein is encoded by the B2M gene. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Beta 2 Microglobulin B2M Antibody Picoband® (monoclonal, 2H10) catalog # M00456-2. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to
Host	Mouse
Immunogen Region	E.coli-derived human Beta 2 Microglobulin recombinant protein (Position: Q22-M119). Human Beta 2 Microglobulin shares 69.4% and 74.5% amino acid (aa) sequence identity with mouse and rat Beta 2 Microglobulin, respectively.
Isotype	Mouse IgG2b
Molecular Weight	12 kDa
Reactivity	Human, Monkey
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Beta-2-microglobulin; Beta-2-microglobulin form pI 5.3; B2M; CDABP0092, HDCMA22P
Tissue Specificity	Expressed in all tissues tested including spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P61769
Gene Id	567
Gene Name	B2M
Clone No	Clone: 2H10
Subcellular Location	Secreted

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> Immunocytochemistry/Immunofluorescence, 2ug/ml<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells<br>

Reference	1. Güssow D, Rein R, Ginjaar I, Hochstenbach F, Seemann G, Kottman A, Ploegh HL (1 November 1987). "The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit". J. Immunol. 139 (9): 31328.<br /><br />2. Munshi NC, Longo DL, Anderson KC (2011). "Chapter 111: Plasma Cell Disorders". In Loscalzo J, Longo DL, Fauci AS, Dennis LK, Hauser SL. Harrison's Principles of Inteal Medicine (18th ed.). McGraw-Hill Professional. pp. 93644.<br /><br />3. Pignone M, Nicoll D; McPhee SJ (2004). Pocket guide to diagnostic tests (4th ed.). New York: McGraw-Hill. p. 191. ISBN 0-07-141184-4.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002040-1	M00456-2	-	100 ug	$370		Add to Cart
BHA21002040-2	M00456-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21002040-3	M00456-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002040-4	M00456-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002040-5	M00456-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002040-6	M00456-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002040-7	M00456-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002040-8	M00456-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21002040-9	M00456-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21002040-10	M00456-2-APC	APC	100 ug	$670		Add to Cart
BHA21002040-11	M00456-2-PE	PE	100 ug	$670		Add to Cart
BHA21002040-12	M00456-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002040-13	M00456-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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