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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Annexin A1

SKU : BHA15100376

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Mfr.No.	AM982-5M
Clonality	Monoclonal
Description	Annexin A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans. Annexin A1 belongs to the annexin family of Ca2+-dependent phospholipid-binding proteins with phospholipase A2 inhibitory activity. In resting conditions, human and mouse immune cells such as neutrophils, monocytes, and macrophages contain high levels of annexin A1 in their cytoplasm. Annexin plays important roles in the innate immune response as an effector of glucocorticoid-mediated responses and regulator of the inflammatory process and has anti-inflammatory activity among its many functions. Annexin A1 also plays a significant role in cancer immunology because it aids in migration and metastasis of tumors. For instance ANXA1s association with NEMO and RIP1 activates NF-kB which in turn promotes breast cancer migration and reduces breast cancer proliferation through a negative feedback. Futhermore, Increased expression of annexin A1 is correlated with K-ras mutation in colorectal cancer. Using immunohistochemistry, expression of annexin A1 is seen in the cytoplasm and membrane of Breast Cancer, tonsil, spleen and lymph node tissue cells.
Host	Mouse
Isotype	IgG2
Reactivity	Human
Species	Mouse

Clone No	ANXA1/1671
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC
Dilution	1:20-40

Product Manual	Datasheet SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
AM982-5M	AM982-5M	6 mL	$319		Add to Cart
AM982-10M	AM982-10M	100 tests - i6000	$608		Add to Cart
AX982-50D	AX982-50D	50 tests - Xmatrx	$336		Add to Cart
AX982-YCD	AX982-YCD	160 tests - Xmatrx	$968		Add to Cart
MU982-UC	MU982-UC	1ml Conc	$438		Add to Cart
MU982-5UC	MU982-5UC	0.5ml Conc	$305		Add to Cart

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