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Home / Primary Antibodies / Monoclonal Antibodies

ALK/CD246

SKU : BHA15100471

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BioGenex Laboratories

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Mfr.No.	AMB41-5M
Clonality	Monoclonal
Description	ALK Antibody also designated CD246 antibody, ALK RTK antibody, or type 1 receptor tyrosine kinase ALK antibody. This antibody recognizes a formalin-resistant epitope in both the 80 kDa NPM-ALK chimeric and the 200 kDa normal human ALK proteins. The wild-type anaplastic lymphoma kinase (ALK) protein expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons, and a few endothelial cells and pericytes). The hybrid gene, NPM-ALK, formed by the chromosomal translocation encodes part of the nucleolar phosphoprotein, nucleophosmin (NPM), adhered to the cytoplasmic portion of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. ALK plays a major in development of brain and can effect specific neurons in nervous system. Recent study shows that the NPM-ALK fusion gene is oncogenic. A truncated form containing the catalytic domain of ALK is expressed as the result of a translocation occurring in many non-Hodgkin?s lymphomas. ALK Antibody stains cytoplasm and nuclear in t(2;5)-positive cells. This antibody helps in the identifying anaplastic large cell lymphoma (ALCL) and also used in a panel with CD15, CD30, TIA-1 and EMA
Host	Mouse
Isotype	IgG2b
Reactivity	Human
Species	Mouse

Clone No	ALK/1031
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC
Dilution	1:10-20

Product Manual	Datasheet SDS

No Description Available.

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Combination SKU	Supplier No.	Size	Your price	Quantity
AMB41-5M	AMB41-5M	6 mL	$293		Add to Cart
AMB41-10M	AMB41-10M	100 tests - i6000	$548		Add to Cart
AXB41-50D	AXB41-50D	50 tests - Xmatrx	$308		Add to Cart
AXB41-YCD	AXB41-YCD	160 tests - Xmatrx	$751		Add to Cart
MUB41-UC	MUB41-UC	1ml Conc	$601		Add to Cart
MUB41-5UC	MUB41-5UC	0.5ml Conc	$420		Add to Cart

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