Midostaurin

Mfr.No.	SIH-468
Alternative Names	4'-N-Benzoyl-staurosporine, PKC-412, CGP 41251
Appearance	White to off-white powder
Function	Kinase inhibitor
Inchi	InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m0/s1
Inchikey	BMGQWWVMWDBQGC-PZFYLCKJSA-N
Mode Of Action	Inhibitor
Molecular Formula	C35H30N4O4
Pubchem Cid	24202429
Sd File	C35H30N4O4 APtclcactv07301413022D 0 0.00000 0.00000 73 81 0 0 1 0 0 0 0 0999 V2000 8.3329 -1.0172 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 9.3329 0.7149 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 6.7081 1.3148 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 6.9669 0.3489 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 5.1349 -0.4100 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 4.8761 0.5560 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 7.2728 -2.4860 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2445 -3.5208 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1306 -4.0560 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0333 -3.5491 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8758 1.3744 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8634 2.4095 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9569 2.9093 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0749 2.3674 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2780 2.0560 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4120 2.5560 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4120 3.5560 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2780 4.0560 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1441 3.5560 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1441 0.5560 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1169 -1.8112 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2395 -1.4045 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2257 -0.6171 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0587 -2.5909 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1441 2.5560 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1588 -0.5832 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.8761 2.5560 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 11.5762 -2.7029 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0101 2.0560 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2214 -0.8167 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 12.4145 -1.2510 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4022 -1.0331 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8814 -1.9352 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.5218 -2.2809 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 10.1113 1.3328 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9816 0.8529 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8744 -0.1351 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8398 -1.9272 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0377 -2.5140 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1870 -2.0002 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0101 1.0560 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4447 2.2974 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 9.3329 -1.0172 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8329 -0.1511 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4881 2.1358 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3842 0.1785 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7459 -2.1594 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7004 -3.8181 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1208 -4.6759 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5677 -3.8635 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8870 -3.2394 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0754 -3.0683 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.4153 1.0687 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.3954 2.7279 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9423 3.5292 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5286 2.6604 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4541 0.0190 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6071 0.2460 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8341 1.0929 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2780 1.4360 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8751 2.2460 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8751 3.8660 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2780 4.6760 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6810 3.8660 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7335 -1.8760 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0521 -2.4278 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5003 -1.7464 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8561 -1.3397 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3043 -2.0211 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6229 -1.4693 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8246 -0.4566 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3862 -1.2159 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6268 -0.7775 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1 43 1 0 0 0 0 1 40 1 0 0 0 0 1 4 1 0 0 0 0 43 44 1 0 0 0 0 38 43 2 0 0 0 0 2 44 1 0 0 0 0 37 44 2 0 0 0 0 2 35 1 0 0 0 0 2 3 1 0 0 0 0 35 36 1 0 0 0 0 14 35 2 0 0 0 0 36 37 1 0 0 0 0 11 36 2 0 0 0 0 32 37 1 0 0 0 0 32 33 2 0 0 0 0 31 32 1 0 0 0 0 33 38 1 0 0 0 0 28 33 1 0 0 0 0 38 39 1 0 0 0 0 39 40 2 0 0 0 0 10 39 1 0 0 0 0 7 40 1 0 0 0 0 7 8 2 0 0 0 0 8 9 1 0 0 0 0 9 10 2 0 0 0 0 28 34 1 0 0 0 0 31 34 1 0 0 0 0 26 31 2 0 0 0 0 11 12 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 3 45 1 6 0 0 0 3 42 1 0 0 0 0 3 6 1 0 0 0 0 4 42 1 0 0 0 0 4 5 1 0 0 0 0 4 23 1 1 0 0 0 5 6 1 0 0 0 0 5 30 1 6 0 0 0 5 22 1 0 0 0 0 6 46 1 0 0 0 0 6 41 1 6 0 0 0 20 41 1 0 0 0 0 29 41 1 0 0 0 0 27 29 2 0 0 0 0 25 29 1 0 0 0 0 15 25 1 0 0 0 0 19 25 2 0 0 0 0 15 16 2 0 0 0 0 16 17 1 0 0 0 0 17 18 2 0 0 0 0 18 19 1 0 0 0 0 21 30 1 0 0 0 0 7 47 1 0 0 0 0 8 48 1 0 0 0 0 9 49 1 0 0 0 0 10 50 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 24 34 1 0 0 0 0 11 53 1 0 0 0 0 12 54 1 0 0 0 0 13 55 1 0 0 0 0 14 56 1 0 0 0 0 20 57 1 0 0 0 0 20 58 1 0 0 0 0 20 59 1 0 0 0 0 15 60 1 0 0 0 0 16 61 1 0 0 0 0 17 62 1 0 0 0 0 18 63 1 0 0 0 0 19 64 1 0 0 0 0 21 65 1 0 0 0 0 21 66 1 0 0 0 0 21 67 1 0 0 0 0 22 68 1 0 0 0 0 22 69 1 0 0 0 0 22 70 1 0 0 0 0 23 71 1 0 0 0 0 23 72 1 0 0 0 0 23 73 1 0 0 0 0 M END $$$$
Research Area	Cell Signaling ; Cancer ; Apoptosis ; Cancer Growth Inhibitors ; Tyrosine Kinase Inhibitors
Safety Phrases	Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Smiles	[N]48C1=C(C7=C(C2=C1[N](C3=CC=CC=C23)[C@@H]5O[C@]4([C@@]([C@@H]5N(C)C(=O)C6=CC=CC=C6)(OC)C)C)C(NC7)=O)C9=C8C=CC=C9
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	120685-11-2
Molecular Weight	570.6
Scientific Background	Midostaurin is a broad spectrum protein kinase inhibitor. It also shows inhibition of PKCα, PKCβ and PKCγ isoforms, Flk, and c-kit. Midostaurin displays antiproliferative characteristics and the ability to induce apoptosis.
Solubility	Soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml) or 100% ethanol (2.5 mg/ml)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.001
Purity	≥98% (TLC)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Fabbro D., et al. (2000) Anti-Cancer Drug Design. 15(1): 17–28. 2. Odgerel, T., et al. (2008) Oncogene. 27(22): 3102–3110. 3. Bahlis, N.J., et al. (2005) Leukemia & Lymphoma. 46(6): 899–908.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900252-2	SIH-468-5MG	5 mg	$443		Add to Cart
BHB11900252-1	SIH-468-1MG	1 mg	$107		Add to Cart

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