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Home / Proteins & Peptide

MCP-2/CCL8, Mouse

SKU : BHP18500106

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iXCells Biotechnologies

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Mfr.No.	IX02854, IX02854-1, IX02854-20
Description	MCP-2 and MCP-3 are two recently identified monocyte chemotactic proteins produced by human MG-63 osteosarcoma cells. Both MCP-2 and MCP-3 are members of the C-C family of chemokines and share 62% and 71% amino acid sequence identity, respectively, with MCP-1. MCP-3 also shares 58% amino acid identity with MCP-2.Similarly to other C-C chemokines, all three MCP proteins are monocyte chemoattractants. In addition, the three MCPs can chemoattract activated NK cells as well as CD4+ and CD8+ T lymphocytes. All three cytokines have also been shown to attract eosinophils and induce histamine secretion from basophils.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <= -20 °C. Further dilutions should be made in appropriate buffered solutions.
Formulation	Lyophilized from a 0.2 um filtered concentrated solution in 20 mM PB, pH 7.4, 150 mM NaCl.
Molecular Weight	Approximately 8.5 kDa, a single, non-glycosylated polypeptide chain containing 74 amino acids.
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Source	E. coli
Host	Mouse
Usage	This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.'
Endotoxin Level	Less than 1 EU/ug of rMuMCP-2/CCL8 as determined by LAL method.
Bioactivity	Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 10-100 ng/ml.

Synonyms	MCP-2/CCL8, Mouse;
Sequence	GPDKAPVTCC FHVLKLKIPL RVLKSYERIN NIQCPMEAVVFQTKQGMSLC VDPTQKWVSE?YMEILDQKSQ ILQP

Purity	97 % by SDS-PAGE and HPLC analyses.
Storage	This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500106-1	IX02854-1	1mg	$2621		Add to Cart
BHP18500106-2	IX02854-20	20ug	$199		Add to Cart

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