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Home / VECTOR &VIRUS / Lentivirus

VDRE Reporter Lentivirus

SKU : BHV19400081

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Mfr.No.	LTV-0088, LTV-0088-1S, LTV-0088-2S, LTV-0088-3S, LTV-0088-4S, LTV-0088-5S, LTV-0088-6S, LTV-0088-15S, LTV-0088-16S
Description	VDRE Reporter Lentivirus: High-quality, lentiviral transcription factor (TF) reporter system that provides a sensitive fluorescent or luminescent readout for human/mouse vitamin D3 receptor (VDR) transcriptional activity in mammalian cells. The VDRE reporter is constructed with tandem repeats of consensus VDR response elements (VDRE) to read out VDR transcriptional activity. Calcitriol, the active form of vitamin D (1,25-dihydroxyvitamin D), binds to VDR, which then forms a heterodimer with the retinoid-X receptor. The VDR heterodimer then enters the nucleus and binds to the VDRE in the gene promoter to be transcriptionally activated or repressed. Vitamin D from the diet and cutaneous synthesis is converted to the active hormone calcitriol by two enzymatic hydroxylation reactions. The first takes place in the liver, mediated by 25-hydroxylase. The second reaction takes place in the kidney, mediated by 1alpha-hydroxylase (CYP27B1). VDR is expressed in most tissues of the body including immune cells. The reporter lentivirus is purified by PEG precipitation and sucrose gradient centrifugation, and is ideal for studying VDR transcriptional activity in difficult-to-transfect cells including primary and/or thawed cells.
Serotype	VSV-G
Reporter	Firefly Luc, RFP, BFP2, GFP
Response Element	Vitamin D response element (VDRE)
Selection	Blasticidin, Puromycin
Signaling pathway	Vitamin D Signaling Pathway (Vitamin D3 receptor)
Species	Human/mouse
Applications Range	Monitor transcriptional activity of VDR in mammalian cells, screen for activators or inhibitors of VDR transcriptional activity. The fluorescent reporter enables convenient readout using flow cytometry, fluorescence microscopy, etc.
Virus Type	TF Reporter Lentivirus

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Combination SKU	Supplier No.	Amount (TU)	Selection	Reporter	Your price	Quantity
BHV19400081-1	LTV-0088-1S	5x10^6	Puromycin	GFP	$595		Add to Cart
BHV19400081-2	LTV-0088-2S	5x10^6	Blasticidin	RFP	$595		Add to Cart
BHV19400081-3	LTV-0088-3S	2x10^6	Puromycin	Firefly Luc	$595		Add to Cart
BHV19400081-4	LTV-0088-4S	2x10^6	Blasticidin	Firefly Luc	$595		Add to Cart
BHV19400081-5	LTV-0088-5S	5x10^6	Blasticidin	GFP	$595		Add to Cart
BHV19400081-6	LTV-0088-6S	5x10^6	Puromycin	RFP	$595		Add to Cart
BHV19400081-7	LTV-0088-15S	5x10^6	Puromycin	BFP2	$595		Add to Cart
BHV19400081-8	LTV-0088-16S	5x10^6	Blasticidin	BFP2	$595		Add to Cart

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