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Home / VECTOR &VIRUS / Lentivirus

T-bet Reporter Lentivirus

SKU : BHV19400071

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Mfr.No.	LTV-0076, LTV-0076-1S, LTV-0076-2S, LTV-0076-3S, LTV-0076-4S, LTV-0076-5S, LTV-0076-6S
Description	T-bet Reporter Lentivirus: High-quality, lentiviral transcription factor (TF) reporter system that provides a sensitive fluorescent or luminescent readout for human/mouse T-bet transcriptional activity in mammalian cells. The T-bet Reporter Lentivirus is constructed with tandem repeats of the consensus T-box transcription factor expressed in T-cells (T-bet or TBX21) response elements, which is transcriptionally responsive to the transcription factor T-bet. T-bet is known for its role in Th1 T cell lineage commitment. T-bet is also involved in immunoglobulin class switching in B lymphocytes. The half site (called a T-half site) is recognized by many other T-box proteins with different optimal target sequences that in part confer target gene specificity. The reporter lentivirus is purified by PEG precipitation and sucrose gradient centrifugation, and is ideal for studying T-bet signaling pathway in difficult-to-transfect cells including primary and/or thawed cells.
Promoter	EF1a
Serotype	VSV-G
Reporter	Firefly Luc, RFP, GFP
Response Element	T-bet response element
Selection	Blasticidin, Puromycin
Signaling pathway	T-bet Signaling Pathway
Species	Human/mouse
Applications Range	Monitor transcriptional activity of T-bet in mammalian cells, screen for activators or inhibitors of T-bet transcriptional activity. The fluorescent reporter enables convenient readout using flow cytometry, fluorescence microscopy, etc. The T-bet Reporter Lentivirus is constructed with tandem repeats of the consensus T-box transcription factor expressed in T-cells (T-bet or TBX21) response elements which is transcriptionally responsive to the transcription factor T-bet. T-bet is primarily known for its role in driving Th1 T cell lineage commitment. T-bet is also involved in immunoglobulin class switching in B lymphocytes. The half site (called a T-half site) is recognized by many other T-box proteins with different optimal target sequences that in part confer target gene specificity.
Virus Type	TF Reporter Lentivirus

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Combination SKU	Supplier No.	Amount (TU)	Selection	Reporter	Promoter	Your price	Quantity
BHV19400071-1	LTV-0076-1S	5x10^6	Puromycin	GFP	EF1a	$595		Add to Cart
BHV19400071-2	LTV-0076-2S	5x10^6	Blasticidin	RFP	EF1a	$595		Add to Cart
BHV19400071-3	LTV-0076-3S	2x10^6	Puromycin	Firefly Luc	EF1a	$595		Add to Cart
BHV19400071-4	LTV-0076-4S	2x10^6	Blasticidin	Firefly Luc	EF1a	$595		Add to Cart
BHV19400071-5	LTV-0076-5S	5x10^6	Blasticidin	GFP	EF1a	$595		Add to Cart
BHV19400071-6	LTV-0076-6S	5x10^6	Puromycin	RFP	EF1a	$595		Add to Cart

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