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Home / VECTOR &VIRUS / Lentivirus

RORgammat Reporter Lentivirus

SKU : BHV19400060

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Mfr.No.	LTV-0065, LTV-0065-1S, LTV-0065-2S, LTV-0065-3S, LTV-0065-4S, LTV-0065-5S, LTV-0065-6S
Description	RORgammat Reporter Lentivirus: High-quality, lentiviral transcription factor (TF) reporter system that provides a sensitive fluorescent or luminescent readout for human/mouse retinoid orphan receptor gamma t (RORgammat) in mammalian cells. The RORgammat reporter contains tandem repeats of transcriptional response elements designed to preferentially readout transcriptional activity of RORgammat vs other ROR isoforms. RORgammat is specifically expressed in immune cells and acts as a direct activator of Th17 signature genes. The reporter lentivirus is purified by PEG precipitation and sucrose gradient centrifugation, and is ideal for studying RORgammat activity in difficult-to-transfect cells including primary and/or thawed cells.
Promoter	GFP, RFP, Firefly Luc
Serotype	VSV-G
Reporter	EF1a
Response Element	RORgammat response elements
Selection	Blasticidin, Puromycin
Signaling pathway	RORgammat
Species	Human/mouse
Applications Range	Monitor RORgammat transcriptional activity in mammalian cells, screen for activators or inhibitors of RORgammat signaling. The fluorescent reporter enables convenient readout using flow cytometry, fluorescence microscopy, etc. The RORgammat reporter utilizes RORgammat response elements that have been optimized preferential binding of RORgammat vs other ROR TFs. RORgammat is considered to be one of the master regulators in the development of T helper 17 cells (Th17 cells), which have an essential role in the development of many autoimmune disorders, including multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease and psoriasis. The tandem repeats of RORgammat DNA-binding elements enable to detect the RORgammat transcriptional activity.
Virus Type	TF Reporter Lentivirus

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Combination SKU	Supplier No.	Amount (TU)	Selection	Reporter	Promoter	Your price	Quantity
BHV19400060-1	LTV-0065-1S	5x10^6	Puromycin	EF1a	GFP	$595		Add to Cart
BHV19400060-2	LTV-0065-2S	5x10^6	Blasticidin	EF1a	RFP	$595		Add to Cart
BHV19400060-3	LTV-0065-3S	2x10^6	Puromycin	EF1a	Firefly Luc	$595		Add to Cart
BHV19400060-4	LTV-0065-4S	2x10^6	Blasticidin	EF1a	Firefly Luc	$595		Add to Cart
BHV19400060-5	LTV-0065-5S	5x10^6	Blasticidin	EF1a	GFP	$595		Add to Cart
BHV19400060-6	LTV-0065-6S	5x10^6	Puromycin	EF1a	RFP	$595		Add to Cart

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