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Home / VECTOR &VIRUS / Lentivirus

PPAR-alpha Reporter Lentivirus

SKU : BHV19400068

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Mfr.No.	LTV-0073, LTV-0073-1S, LTV-0073-2S, LTV-0073-3S, LTV-0073-4S, LTV-0073-5S, LTV-0073-6S
Description	PPARalpha Reporter Lentivirus: High-quality, lentiviral transcription factor (TF) reporter system that provides a sensitive fluorescent or luminescent readout for human/mouse peroxisome proliferator-activated receptor alpha (PPAR-alpha, PPARA, or PPAR-alpha) activity in mammalian cells. The PPARalpha reporter construct was designed for preferential activation by PPARalpha and RXRalpha heterodimers and is more strongly activated by PPARalpha vs PPARgamma. The construct contains tandem repeats of PPRE element from the Acox1 promoter driving the reporter gene. PPARalpha is expressed highly in the liver and functions to control lipid metabolism, especially fatty acid oxidation. The reporter lentivirus is purified by PEG precipitation and sucrose gradient centrifugation, and is ideal for studying PPAR signaling pathways in difficult-to-transfect cells including primary and/or thawed cells.
Promoter	EF1a
Serotype	VSV-G
Reporter	Firefly Luc, RFP, GFP
Response Element	PPAR response element (PPRE), optimized for PPAR-alpha
Selection	Blasticidin, Puromycin
Signaling pathway	PPAR signaling pathway (PPAR-alpha)
Species	Human/mouse
Applications Range	Monitor PPAR-alpha activity, test for inhibitors of PPAR-alpha-mediated transcriptional activity. The PPARalpha reporter construct was optimized to allow for preferential activation by PPARalpha and RXRalpha heterodimers within peroxisome proliferator receptor elements (PPRE) in the genes regulated by PPARalpha. Tandem repeats of PPRE element on the Acox1 promoter of PPARalpha target gene can read out its transcriptional activity better than PPARgamma in mammalian cells. PPARalpha is expressed highly in the liver and functions to control lipid metabolism, especially fatty acid oxidation.
Virus Type	TF Reporter Lentivirus

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Combination SKU	Supplier No.	Amount (TU)	Selection	Reporter	Promoter	Your price	Quantity
BHV19400068-1	LTV-0073-1S	5x10^6	Puromycin	GFP	EF1a	$595		Add to Cart
BHV19400068-2	LTV-0073-2S	5x10^6	Blasticidin	RFP	EF1a	$595		Add to Cart
BHV19400068-3	LTV-0073-3S	2x10^6	Puromycin	Firefly Luc	EF1a	$595		Add to Cart
BHV19400068-4	LTV-0073-4S	2x10^6	Blasticidin	Firefly Luc	EF1a	$595		Add to Cart
BHV19400068-5	LTV-0073-5S	5x10^6	Blasticidin	GFP	EF1a	$595		Add to Cart
BHV19400068-6	LTV-0073-6S	5x10^6	Puromycin	RFP	EF1a	$595		Add to Cart

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