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Home / VECTOR &VIRUS / Lentivirus

NKp46 Lentivirus (Macaca fascicularis/Cynomolgus)

SKU : BHV18200014

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BPS Bioscience

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Mfr.No.	78779
Description	The NKp46 Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles ready to transduce nearly all types of mammalian cells, including primary and non-dividing cells. These viruses transduce cells with Macaca fascicularis (also known as crab-eating macaque or cynomolgus monkey) NKp46 (Q95JB9.1) driven by an EF1A promoter. The lentiviruses also transduce a puromycin selection gene. NKp46 (also known as Natural Cytotoxicity Triggering Receptor 1, NCR1, and CD335) is an important NK-activating receptor expressed on the surface of human NK (natural killer) cells, involved in cellular cytotoxicity. NKp46 participates in the activation of NK cells against pathogens, tumor cells, and virally infected cells; it also plays an important role in autoimmune conditions. NKp46 expression level can be used as a prognostic tool in acute myeloid leukemia (AML). Due to its crucial role in NK cell activity NKp46 has been used in multiple therapeutical approaches, such as trifunctional NK cell engagers (combined with CD16 and a cancer target) and strategies aimed at increasing NKp46 expression to generate higher NK cell-mediated cytotoxicity. The lentivirus particles were produced in HEK293T cells in medium containing 90% DMEM + 10% FBS. Virus particles can be packaged in custom formulations by special request, for an additional fee. Biosafety None of the HIV genes (gag, pol, rev) will be expressed in the transduced cells, as they are expressed from packaging plasmids lacking the packing signal and are not present in the lentivirus particle. Although the pseudotyped lentiviruses are replication-incompetent, they require the use of a Biosafety Level 2 facility. BPS Bioscience recommends following all local federal, state, and institutional regulations and using all appropriate safety precautions.
Synonyms	CD335, Natural Cytotoxicity Triggering Receptor 1, Lymphocyte Antigen 94 Homolog, and Natural Killer Cell P46-Related Protein
Applications Range	Expression of NKp46 in cells of interest. Generate stable cell lines expressing cynomolgus NKp46 (puromycin resistant).
Storage	Lentiviruses are shipped with dry ice. For long-term storage, it is recommended to store the lentiviruses at -80°C for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. Titers can drop significantly with each freeze/thaw cycle.
Shipping	-80°C

Expression of NKp46 CHO-K1 cells using cynomolgus NKp46 lentivirus.

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SKU	Supplier No.	Size	Your price	Quantity
BHV18200014	78779	500 µl x 2	$850		Add to Cart

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