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Home / VECTOR &VIRUS / Lentivirus

FOXQ1 Reporter Lentivirus

SKU : BHV19400093

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Mfr.No.	LTV-0102, LTV-0102-1S, LTV-0102-2S, LTV-0102-3S, LTV-0102-4S, LTV-0102-5S, LTV-0102-6S, LTV-0102-15S, LTV-0102-16S
Description	FOXQ1 Reporter Lentivirus: High-quality, lentiviral transcription factor (TF) reporter system that provides a sensitive fluorescent or luminescent readout for human/mouse forkhead box transcription factor (FOXQ1) transcriptional activity in mammalian cells. The FOXQ1 reporter is constructed with tandem repeats of a composite sequence containing consensus FOXQ1 DNA-binding elements and GGAA microsatellites to read out synergistic transcriptional activities of FOXQ1 and EWS-FLI1 in mammalian cells. FOXQ1 is a weak transcriptional activator but can be exacerbated in cancer by cooperating with or activating oncogenic proteins to promote tumor progression and metastasis. EWS-FLI1 is a chimeric transcription factor caused by EWS chromosomal translocations. The fusion protein EWS-FLI1 is found in 85% of human Ewing sarcoma, a highly aggressive and metastatic cancer in children and adolescents. EWS-FLI1 directly binds to GGAA microsatellites in enhancers and promotors of target genes. In particular, Foxq1 was identified as the cooperative partner for EWS-FLI1. Direct targeting of EWS-FLI1 is challenging due to the disordered structure. The FOXQ1 reporter takes advantage of the cooperation between FOXQ1 and EWS-FLI1 to monitor how they dysregulate critical targets for cancer reprograming and aggressiveness and could be applied for drug discovery/development. The FOXQ1 reporter lentivirus is purified by PEG precipitation and sucrose gradient centrifugation and is ideal for studying FOXQ1 and EWS-FLI1 coordinated transcriptional activities in difficult-to-transfect cells including primary and/or thawed cells.
Serotype	VSV-G
Reporter	Firefly Luc, RFP, BFP2, GFP
Response Element	FOXQ1 response element
Selection	Blasticidin, Puromycin
Signaling pathway	FOXQ1 Signaling Pathway
Species	Human/mouse
Applications Range	Monitor FOXQ1 transcriptional activity in mammalian cells, screen for activators or inhibitors of FOXQ1 transcriptional activity. The fluorescent reporter enables convenient readout using flow cytometry, fluorescence microscopy, etc.
Virus Type	TF Reporter Lentivirus

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Combination SKU	Supplier No.	Amount (TU)	Selection	Reporter	Your price	Quantity
BHV19400093-1	LTV-0102-1S	5x10^6	Puromycin	GFP	$595		Add to Cart
BHV19400093-2	LTV-0102-2S	5x10^6	Blasticidin	RFP	$595		Add to Cart
BHV19400093-3	LTV-0102-3S	2x10^6	Puromycin	Firefly Luc	$595		Add to Cart
BHV19400093-4	LTV-0102-4S	2x10^6	Blasticidin	Firefly Luc	$595		Add to Cart
BHV19400093-5	LTV-0102-5S	5x10^6	Blasticidin	GFP	$595		Add to Cart
BHV19400093-6	LTV-0102-6S	5x10^6	Puromycin	RFP	$595		Add to Cart
BHV19400093-7	LTV-0102-15S	5x10^6	Puromycin	BFP2	$595		Add to Cart
BHV19400093-8	LTV-0102-16S	5x10^6	Blasticidin	BFP2	$595		Add to Cart

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