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Home / VECTOR &VIRUS / Lentivirus

FOXC2 Reporter Lentivirus

SKU : BHV19400057

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Mfr.No.	LTV-0061, LTV-0061-1S, LTV-0061-2S, LTV-0061-3S, LTV-0061-4S, LTV-0061-5S, LTV-0061-6S
Description	FOXC2 Reporter Lentivirus: High-quality, lentiviral transcription factor (TF) reporter system that provides a sensitive fluorescent or luminescent readout for human/mouse Forkhead box C2 in mammalian cells. There are nearly 50 forkhead TFs encoded in the human genome, which share a similar core DNA binding element, but differ in the flanking sequences that confer binding specificity for different forkhead TFs. The FOXC2 reporter is designed to preferentially readout transcriptional activity of FOXC2 vs other forkhead TFs. FOXC2 controls the expression of genes involved in normal developmental processes such as the formation of veins and the development of the lungs, eyes, kidneys and urinary tract, cardiovascular system, and the transport system for immune cells (lymphatic vessels). The tandem repeats of FOXC2 DNA binding element enable to detect the activity of FOXC2 and the signaling pathways for its activation. The reporter lentivirus is purified by PEG precipitation and sucrose gradient centrifugation, and is ideal for studying FOXC2 activity in difficult-to-transfect cells including primary and/or thawed cells.
Promoter	EF1a
Serotype	VSV-G
Reporter	Firefly Luc, RFP, GFP
Response Element	FOXC2
Selection	Blasticidin, Puromycin
Signaling pathway	Forkhead Transcription Factors (FOXC2)
Species	Human/mouse
Applications Range	Monitor FOXC2 activity in mammalian cells, screen for activators or inhibitors of FOXC2 signaling. The fluorescent reporter enables convenient readout using flow cytometry, fluorescence microscopy, etc. There are nearly 50 forkhead transcription factors (TFs) encoded in the human genome, all of which share a similar core DNA binding element, but differ in the flanking sequences that confer binding specificity for different forkhead TFs. The forkhead transcription factor FOXC2 reporter is designed to preferentially readout transcriptional activity of FOXC2 vs other forkhead TFs in mammalian cells. FOXC2 controls the expression of genes involved in the normal developmental processes and maintenances such as the lymphatic vesicular formation, and the development of the lungs, eyes, kidneys and urinary tract, cardiovascular system. The tandem repeats of FOXC2 DNA binding element enable to detect the activity of FOXC2 and the signaling pathways for its activation.
Virus Type	TF Reporter Lentivirus

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Combination SKU	Supplier No.	Amount (TU)	Selection	Reporter	Promoter	Your price	Quantity
BHV19400057-1	LTV-0061-1S	5x10^6	Puromycin	GFP	EF1a	$595		Add to Cart
BHV19400057-2	LTV-0061-2S	5x10^6	Blasticidin	RFP	EF1a	$595		Add to Cart
BHV19400057-3	LTV-0061-3S	2x10^6	Puromycin	Firefly Luc	EF1a	$595		Add to Cart
BHV19400057-4	LTV-0061-4S	2x10^6	Blasticidin	Firefly Luc	EF1a	$595		Add to Cart
BHV19400057-5	LTV-0061-5S	5x10^6	Blasticidin	GFP	EF1a	$595		Add to Cart
BHV19400057-6	LTV-0061-6S	5x10^6	Puromycin	RFP	EF1a	$595		Add to Cart

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