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IRF4 Antibody

SKU : BHA10557927

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA250376
Alternative Names	interferon regulatory factor 4; LSIRF; lymphocyte-specific interferon regulatory factor; multiple myeloma oncogene 1; MUM1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes By similarity.Grossman A., Genomics 37:229-233(1996).Iida S., Nat. Genet. 17:226-230(1997).Mungall A.J., Nature 425:805-811(2003).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human IRF4.
Involvement In Disease	Multiple myeloma (MM)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes By similarity. Grossman A., Genomics 37:229-233(1996). Iida S., Nat. Genet. 17:226-230(1997). Mungall A.J., Nature 425:805-811(2003).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total IRF4 protein.
Subcellular Location	Nucleus

Uniprot	Q15306
Database Links	HGNC:6119 OMIM:254500 KEGG:hsa:3662 STRING:9606.ENSP00000370343 UniGene:Hs.401013
Function	Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).
Pathway	Th17 cell differentiation
Protein Families	IRF family
Tissue Specificity	Lymphoid cells.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557927	CSB-PA250376	100ul	$297		Add to Cart

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