R26-pVillin1-hCYP3A4-IRES-tdTomato(FVB)

Mfr.No.	NM-KI-18033
Description	Intestinal expression of the CYP3A enzyme in the human body can cause significant intestinal metabolism of the compound, resulting in impaired drug absorption. This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the Villin1 promoter together with the IRES-tdTomato reporter gene into mosue Rosa26 site, which can be crossed with the Cyp3a13 gene knockout and other Cyp3a family genes knockout mice to obtain intestinal-expressed CYP3A4 humanized mouse model in order to determine the contribution of intestinal metabolism to the absorption and distribution of test article. NCBI ID: 14910 MGI ID: 104735 Ensembl ID: ENSMUSG00000086429 Pubmed: Gt(ROSA)26Sor Human Ortholog: On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
Nomenclature	FVB-Gt(ROSA)26Sor^{em1(Gut-CYP3A4-IRES-tdTomato)Smoc}
Strain	Embryo cryopreservation
KI/KO Gene	Gt(ROSA)26Sor
Synonyms	R26,ROSA26,AV258896,Gtrgeo26,Gtrosa26,Thumpd3as1

Research Application	Metabolism, Humanized Drug Targets

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