The endogenous human HLA-E gene (about 11kb) was knocked into the H11 locus via CRISPR/Cas9 mediated recombination.
MGI ID: 5461148
Human Ortholog: On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
Nomenclature
C57BL/6Smoc-Igs2em1(hHLA-E)Smoc
Strain
Embryo cryopreservation
Synonyms
H11,Hipp11,Iis2
Research Application
Tumor Research, Drug screening, Humanized Drug Targets