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Home / Proteins & Peptide

IL-33, Human

SKU : BHP18500353

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iXCells Biotechnologies

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Mfr.No.	IX03198, IX03198-1, IX03198-10, IX03198-50
Description	Interleukin-33 (IL-33) is a proinflammatory cytokine that belongs to the IL-1 family. IL-33 is expressed in a variety of cells, including epithelial and endothelial cells, smooth muscle cells, macrophages and fibroblasts. The primary receptors for IL-33 are ST2 and IL-1 receptor accessory protein (IL-1RAcP), both of which belong to the IL-1 receptor family. IL-33 is localized to the nucleus of resting cells where it binds to chromatin in the H2A-H2B histone complex as a transcriptional suppressor. IL-33 is secreted by cells during injury which induces a T-helper 2 type inflammatory response. Evidence suggests IL-33 plays a role in autoimmune disease. IL-33 s interaction with ST2 can drive allergic pathology and IL-33 has been reported to play a role in the development of rheumatoid arthritis and systemic lupus erythematosus.Recombinant humanInterleukin-33 (rhIL-33) produced in E. coli is a single non-glycosylated polypeptide chain containing 159 amino acids. A fully biologically active molecule, rhIL-33 has a molecular mass of 18.0 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques.
Reconstitution	Reconstituted in ddH2O at 100 ug/mL.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	18.0 kDa, observed by reducing SDS-PAGE.
Source	E. coli
Host	Human
Accession Number	O95760
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 0.5ng/mL, measured by a cell proliferation assay using D10S cells, corresponding to a specific activity of 2x 106 units/mg.

Synonyms	IL-1F11, NF-HEV
Sequence	SITGISPITE YLASLSTYND QSITFALEDE SYEIYVEDLKKDEKKDKVLL SYYESQHPSN ESGDGVDGKM LMVTLSPTKDFWLHANNKEH SVELHKCEKP LPDQAFFVLH NMHSNCVSFECKTDPGVFIG VKDNHLALIK VDSSENLCTE NILFKLSET

Purity	95% by SDS-PAGEanalysis.
Storage	Lyophilized recombinant human Interleukin-33 (rhIL-33) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhIL-33 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500353-1	IX03198-1	1mg	$2621		Add to Cart
BHP18500353-2	IX03198-10	10ug	$107		Add to Cart
BHP18500353-3	IX03198-50	50ug	$344		Add to Cart

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